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21st Century, Flea + Tick Defense for Dogs 45-88 lbs., 3 Applicators, .091 fl oz Each

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In Stock
  • Expiration Date: Jan 2021
  • Shipping Weight: 0.18 lbs (0.08 kg)
  • Product Code: CEN-00052
  • UPC Code: 026664000521
  • Package Quantity: 3 Applicators, .091 fl oz Each
  • Dimensions: 0.7 x 5.8 x 4.4 in, 0.1 lbs (0.05 kg)
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Product Overview


Contains Fipronil the active ingredient used in FrontlineĀ® - Top Spot for Dogs*

  • Fast-Acting, Long-Lasting
  • Kills Fleas
  • Kills Ticks
  • Kills Chewing Lice
  • Waterproof

Kills Fleas, Ticks & Lice

Flea + Tick Defense for Dogs contains the active ingredient fipronil that effectively targets fleas, ticks, and chewing lice. Fipronil collects in the oils of the skin and hair follicles, and continues to be released from hair follicles onto the skin and coat, resulting in long-lasting activity.


  • Kills adult fleas before they lay eggs
  • Controls flea re-infestation for up to one month (4 weeks)
  • Controls fleas which may cause flea allergy dermatitis


  • Kills ticks that may transmit Lyme disease, Rocky Mountain spotted fever, ehrlichiosis, and babesiosis


  • Rapidly eliminates infestations with chewing lice


  • Aids in control of sarcoptic mange infestations

Suggested Use

For Dogs and Puppies - 45-88 lbs and 8 weeks or older

Other Ingredients

Active Ingredient %
Fipronil 9.7%
Other Ingredients 90.3%
Total 100.0%

Contains Fipronil the active ingredient used in Frontline Top Spot for Dogs

*FrontlineĀ® and Frontline Top Spot for DogsĀ® are registered trademarks of Merial.


Caution: Keep out of reach of children

See label insert for precautionary and first aid statements.

Do not use on cats. Keep cats away from treated dogs for 24 hours. If applied to a cat or ingested by a cat, contact your veterinarian.

iHerb Customer Reviews

Works great!

Posted by 5722196552674183406 on Aug 03, 2016

Works great and a less expensive alternative to Frontline.

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Posted by 5719440760214590466 on Jul 10, 2016

Living in a warm climate, we have flees year-round, and a lot of them in summer. When they are all over, they bite me, too... This product seems to keep them under control. My dog hardly scratches and I have not been bitten. Hurray! :)

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Happy Dog

Posted by 5187351105252543108 on Jan 19, 2015

Good price and does the job. My dog has skin allergies and this helps stop any allergies which is great.

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nice :)

Posted by 4623578422451112027 on Dec 10, 2014

lasted for 3.5 weeks, which is normal for this product but I thought it will effect for more time.

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Flea and tick defense

Posted by Reviewer1255886 on Sep 29, 2014

I am on the second month of using this on my 55lb lab mix, and haven't quite made up my mind as to whether I will repurchase or not. Seems to work fairly well for about 2 weeks, then not so well. That said, I am in Florida and the fleas here are on steriods I think.

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