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Doctor's Best, SAM-e (S-Adenosyl-L-Methionine) 400, Double-Strength, 30 Enteric Coated Tablets

By Doctor's Best

MSRP:
$39.99
Our Price:
$18.74
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$21.25 (53%)
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In Stock
  • Product Code: DRB-00151
  • UPC Code: 753950001510
  • Package Quantity: 30 Enteric Coated Tablets
  • Dimensions: 1.8 x 3.3 x 6.3 in, 0.15 lbs (0.07 kg)

Product Overview

Description
  • Science-Based Nutrition
  • Dietary Supplement with 400 mg Active S-Adenosyl Methionine Per Tablet
  • Enhances Mood & Neural Function
  • Promotes Joint Comfort & Mobility
  • Supports Liver Health & Detoxification
  • Pharmaceutical Grade
  • Sealed in Blister Packs for Freshness & Convenience
  • Suitable for Vegetarians

S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.

Supplementing with SAMe

The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market.

SAMe and Joint Function

SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.

SAMe and Neural Health

SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.

SAMe and Liver Function

SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.

Our Double-Strength SAMe 400 contains 400 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.

Double-Strength SAMe is sealed in blister packs for freshness and stability.

Suggested Use

Adult Use: Take 1 tablet daily away from food, or as recommended by a nutritionally-informed physician. Do not chew or crush tablet.

Other Ingredients

Cellulose, methacrylic acid copolymer, glyceryl behenate, magnesium silicate, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silicon dioxide, medium chain triglycerides, sodium carboxymethyl starch and iron oxide.

The SAMe found in Doctor's Best SAMe 400 mg (Double Strength) is free from yeast, dairy, gluten, soy, wheat and artificial flavoring.

Contains nothing other than listed ingredients

Warnings

Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.

Store product in a cool, dry place to ensure maximum quality.

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Supplement Facts
Serving Size: 1 tablet
Servings Per Container: 30 servings
  Amount per serving % Daily Value
S-Adenosyl Methionine (from 800 mg of SAMe tosylate disulfate) 400 mg
† Daily Value not established.

iHerb Customer Reviews

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Ahhh Found it !

Posted by Reviewer3003083 on Nov 01, 2010

I recently went off Prozac....I just slept All the time. I decided to try some Sam-e. Unfortunately, I tried three other brands before Doctor's best. The others made me sleep...I was neither happy or sad...just sleepy. Dr. Best was the only one that made me perk up and WANT to do things...I'm not exaggerating ...I guess everyone's brain is different and we all have different reactions . This one is the one for me...Finally I found my match. If I could give this product 6...8..20 stars...I would.

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21 people found the following review helpful

Wonderful for taking the edge off

Posted by Reviewer3291104 on May 01, 2010

We bought both the 200mg and 400mg dose. We bought both because I worry a lot and that increased with the onset of perimenopause. The SAM-e has helped my whole family. That tightness from worrying is gone - as well as the worrying. When I feel the anxious, I take a 400mg pill. I read in Mind Boosters by Ray Sahelian M.D. that he took 800mg dose throughout the day without side effects. I haven't taken more than 600mg in one day and have not experienced any side effects. SAM-e takes the edge off - like a glass of wine only without the calories and it lasts a lot longer.

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15 people found the following review helpful

Ridiculously good price

Posted by Reviewer3088906 on Feb 02, 2008

SAMe is ludicrously overpriced, but Doctor's Best outcompetes other brands by far. Clinical studies only show a major benefit at high doses (1200 mg/day), but it can be a remarkably effective antidepressant. I heard this lecture by a psychiatrist on alternative medicine in the treatment of mood disorders -- because patients respond to SAMe so rapidly, she said that she often used it during the early stages of SSRI or other anti-depressant therapy to help patients get relief faster. Response times to SAMe are on the order of around 2 weeks vs the 4 weeks usually required for most other ADs. (NOTE: Talk to your doctor or psychiatrist about using SAMe as an adjuvant to antidepressant therapy, and *definitely* if you plan on using SAMe in place of traditional therapy.)

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14 people found the following review helpful

The best SAM-e!

Posted by Reviewer2647370 on Jul 01, 2008

I have had amazing results with Dr's Best SAM-e. I chose it because it is double strength and is the genuine SAM-e from Italy. Within 10 days I started to notice a lift in my mood and less anxiety. After a month, I felt like a different person. I have never felt this way before in my life. I will continue with it every day. I feel great!

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14 people found the following review helpful

Never Take Sam-e without Vitamins B-complex

Posted by Reviewer1327018 on Nov 07, 2008

I have been taking this over a month now. good results untill one day i felt fast heart beat and short breath. did some study and took B-complex. Made my heart back to normal in minutes. once again, this is an excelent product but do not take it without vitamin B-COMPLEX.

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14 people found the following review helpful

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