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Doctor's Best, SAM-e (S-Adenosyl-L-Methionine) 400, Double-Strength, 30 Enteric Coated Tablets

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In Stock
  • Expiration Date: Feb 2019
  • Shipping Weight: 0.37 lbs (0.17 kg)
  • Product Code: DRB-00151
  • UPC Code: 753950001510
  • Package Quantity: 30 Enteric Coated Tablets
  • Dimensions: 1.8 x 3.3 x 6.3 in, 0.15 lbs (0.07 kg)
Product Overview


  • Science-Based Nutrition
  • Dietary Supplement with 400 mg Active S-Adenosyl Methionine Per Tablet
  • Enhances Mood & Neural Function
  • Promotes Joint Comfort & Mobility
  • Supports Liver Health & Detoxification
  • Pharmaceutical Grade
  • Sealed in Blister Packs for Freshness & Convenience
  • Suitable for Vegetarians

S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.

Supplementing with SAMe

The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market.

SAMe and Joint Function

SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.

SAMe and Neural Health

SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.

SAMe and Liver Function

SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.

Our Double-Strength SAMe 400 contains 400 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.

Double-Strength SAMe is sealed in blister packs for freshness and stability.

Suggested Use

Adult Use: Take 1 tablet daily away from food, or as recommended by a nutritionally-informed physician. Do not chew or crush tablet.

Other Ingredients

Cellulose, methacrylic acid copolymer, glyceryl behenate, magnesium silicate, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silicon dioxide, medium chain triglycerides, sodium carboxymethyl starch and iron oxide.

The SAMe found in Doctor's Best SAMe 400 mg (Double Strength) is free from yeast, dairy, gluten, soy, wheat and artificial flavoring.

Contains nothing other than listed ingredients


Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.

Store product in a cool, dry place to ensure maximum quality.

Supplement Facts
Serving Size: 1 tablet
Servings Per Container: 30 servings
  Amount per serving % Daily Value
S-Adenosyl Methionine (from 800 mg of SAMe tosylate disulfate) 400 mg
† Daily Value not established.
iHerb Customer Reviews

Good Quality and Very Effective

Posted by 4922689878031739880 on Oct 22, 2016

I take this for my mood. It takes about 2 to3 days to work. You can almost notice the difference almost immediately.

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I guess it helps

Posted by 4675693113332834525 on Oct 11, 2016

My therapist recommended these since I have the MTHFR gene mutation. It is difficult to say if and how do they work, because I feel fine!

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Posted by 5323983133046799948 on Oct 10, 2016

Seems to do the same thing the much more expensive items .

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Great to calm

Posted by MissBunnyStrut on Sep 18, 2016

Experiencing anxiety in combination with aches and pains I came across SAM-e. I waited two weeks to write a review so that I would have time to test the product. So far, I have felt that the tablet has helped me feel much more calm and positive in addition to relieving back pain that I experience without leaving me feeling like I'm 'on something'. The effects have been gentle and positive. I take my tablet first thing in the morning before I shower, this way by the time I'm out, dressed, makeup done, I am able to have something for breakfast without risking that I would upset my stomach. I would recommend these tablets to anyone who feels like they need a little support for their body and mind. Thank you.

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Depression prevention

Posted by 5239059776918062918 on Sep 10, 2016

I use Doctor's Best SAMe to keep my depression at bay. It works really well and I will continue to use it successfully.

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