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- Science-Based Nutrition
- Dietary Supplement with 400 mg Active S-Adenosyl Methionine Per Tablet
- Enhances Mood & Neural Function
- Promotes Joint Comfort & Mobility
- Supports Liver Health & Detoxification
- Pharmaceutical Grade
- Sealed in Blister Packs for Freshness & Convenience
- Suitable for Vegetarians
S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.
Supplementing with SAMe
The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market.
SAMe and Joint Function
SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.
SAMe and Neural Health
SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.
SAMe and Liver Function
SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.
Our Double-Strength SAMe 400 contains 400 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.
Double-Strength SAMe is sealed in blister packs for freshness and stability.
Adult Use: Take 1 tablet daily away from food, or as recommended by a nutritionally-informed physician. Do not chew or crush tablet.
Cellulose, methacrylic acid copolymer, glyceryl behenate, magnesium silicate, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silicon dioxide, medium chain triglycerides, sodium carboxymethyl starch and iron oxide.
The SAMe found in Doctor's Best SAMe 400 mg (Double Strength) is free from yeast, dairy, gluten, soy, wheat and artificial flavoring.
Contains nothing other than listed ingredients
Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.
Store product in a cool, dry place to ensure maximum quality.
|Serving Size: 1 tablet|
|Servings Per Container: 30 servings|
|Amount per serving||% Daily Value|
|S-Adenosyl Methionine (from 800 mg of SAMe tosylate disulfate)||400 mg||†|
|† Daily Value not established.|
I recently went off Prozac....I just slept All the time. I decided to try some Sam-e. Unfortunately, I tried three other brands before Doctor's best. The others made me sleep...I was neither happy or sad...just sleepy. Dr. Best was the only one that made me perk up and WANT to do things...I'm not exaggerating ...I guess everyone's brain is different and we all have different reactions . This one is the one for me...Finally I found my match. If I could give this product 6...8..20 stars...I would.
SAMe is ludicrously overpriced, but Doctor's Best outcompetes other brands by far. Clinical studies only show a major benefit at high doses (1200 mg/day), but it can be a remarkably effective antidepressant. I heard this lecture by a psychiatrist on alternative medicine in the treatment of mood disorders -- because patients respond to SAMe so rapidly, she said that she often used it during the early stages of SSRI or other anti-depressant therapy to help patients get relief faster. Response times to SAMe are on the order of around 2 weeks vs the 4 weeks usually required for most other ADs. (NOTE: Talk to your doctor or psychiatrist about using SAMe as an adjuvant to antidepressant therapy, and *definitely* if you plan on using SAMe in place of traditional therapy.)
Posted by 5189763616648102734 on Dec 01, 2016
Never wthout this product! Running out shows how well it works!
Natural Seratonin stimulant ****
Posted by 5131948439234003167 on Dec 01, 2016
My daughter suffers from low mood and never found prescription pills good and also didn't want taking such strong chemicals all the time so she has been taking these and there is a definite improvement in her overall mood
Recommended by my GP
Posted by Reviewer2815139 on Nov 30, 2016
This brand of SAMe was recommended by my alternative health GP in Australia due to its high quality and reasonable price. I have had no trouble tolerating 800mg per day. It is too early to tell if I have any benefits from it.
Good Quality and Very Effective
Posted by 4922689878031739880 on Oct 22, 2016
I take this for my mood. It takes about 2 to3 days to work. You can almost notice the difference almost immediately.