Doctor's Best, SAM-e (S-Adenosyl-L-Methionine) 400, Double-Strength, 30 Enteric Coated Tablets
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- Science-Based Nutrition
- Dietary Supplement with 400 mg Active S-Adenosyl Methionine Per Tablet
- Enhances Mood & Neural Function
- Promotes Joint Comfort & Mobility
- Supports Liver Health & Detoxification
- Pharmaceutical Grade
- Sealed in Blister Packs for Freshness & Convenience
- Suitable for Vegetarians
S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.
Supplementing with SAMe
The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market.
SAMe and Joint Function
SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.
SAMe and Neural Health
SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.
SAMe and Liver Function
SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.
Our Double-Strength SAMe 400 contains 400 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.
Double-Strength SAMe is sealed in blister packs for freshness and stability.
Adult Use: Take 1 tablet daily away from food, or as recommended by a nutritionally-informed physician. Do not chew or crush tablet.
Cellulose, methacrylic acid copolymer, glyceryl behenate, magnesium silicate, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silicon dioxide, medium chain triglycerides, sodium carboxymethyl starch and iron oxide.
The SAMe found in Doctor's Best SAMe 400 mg (Double Strength) is free from yeast, dairy, gluten, soy, wheat and artificial flavoring.
Contains nothing other than listed ingredients
Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.
Store product in a cool, dry place to ensure maximum quality.
|Serving Size: 1 tablet|
|Servings Per Container: 30 servings|
|Amount per serving||% Daily Value|
|S-Adenosyl Methionine (from 800 mg of SAMe tosylate disulfate)||400 mg||†|
|† Daily Value not established.|
iHerb Customer Reviews
I recently went off Prozac....I just slept All the time. I decided to try some Sam-e. Unfortunately, I tried three other brands before Doctor's best. The others made me sleep...I was neither happy or sad...just sleepy. Dr. Best was the only one that made me perk up and WANT to do things...I'm not exaggerating ...I guess everyone's brain is different and we all have different reactions . This one is the one for me...Finally I found my match. If I could give this product 6...8..20 stars...I would.
I have been taking this over a month now. good results untill one day i felt fast heart beat and short breath. did some study and took B-complex. Made my heart back to normal in minutes. once again, this is an excelent product but do not take it without vitamin B-COMPLEX.
Posted by 4993142139333910637 on May 05, 2016
I have jumopers knee and this thing is the only thing that helped. I have taken NSAIDs and they helped some what but the motility of my knee was always decreased. This thing helped me so much! It made my mood much better too! This is way better than MSM IMO!!
Posted by 5443300568896328638 on Apr 01, 2016
It is very good product for improving liver function. I really happy to find it here. It helped me to eliminate bitterness in my mouth. I used it with r-lipoic acid and mega-pc and l-glutamin.
Didn't work for me
Posted by 4846739210802950254 on Mar 21, 2016
Completely useless product.
Posted by 5407946756973564481 on Jan 17, 2016
Wonderful product.. It really works and give me a great boost from the first day Highly recommend it
Helps the Joints
Posted by Reviewer2860699 on Dec 13, 2015
As I get older, (65 ) my joints have been giving me some grief... not arthritis, just weak and aching. I have tried various remedies. After using SAMe for a month in a less potent formula (200 mg) I switched to this brand and 400 mg. After a few weeks, I noticed a definite improvement with joints aching less. As for any effects on mood... maybe there's a little less gloominess, but this is not so obvious.