EN
USD

Customize Your Shopping Experience!

Please select the destination country, language, and currency you prefer.

1
2
3
Available Shipping Methods
Available Payment Methods
Added to Cart
Total:
Combo Discount:
Together:
Quantity:
View/Edit Cart Checkout
Cart Total:
Customers Also Bought:

Doctor's Best, SAM-e (S-Adenosyl-L-Methionine) 400, Double-Strength, 30 Enteric Coated Tablets

By Doctor's Best

MSRP:
$39.99
Our Price:
$18.74
You Save:
$21.25 (53%)
  • Volume Discount
  • Buy 4+
    Save 5%
Earn 10% Loyalty Credit ?

This product is already in your Wish List.


View Wish List

This product is now in your Wish List.

In Stock
  • Product Code: DRB-00151
  • UPC Code: 753950001510
  • Package Quantity: 30 Enteric Coated Tablets
  • Dimensions: 1.8 x 3.3 x 6.3 in, 0.15 lbs (0.07 kg)

Product Overview

Description
  • Science-Based Nutrition
  • Dietary Supplement with 400 mg Active S-Adenosyl Methionine Per Tablet
  • Enhances Mood & Neural Function
  • Promotes Joint Comfort & Mobility
  • Supports Liver Health & Detoxification
  • Pharmaceutical Grade
  • Sealed in Blister Packs for Freshness & Convenience
  • Suitable for Vegetarians

S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.

Supplementing with SAMe

The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market.

SAMe and Joint Function

SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.

SAMe and Neural Health

SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.

SAMe and Liver Function

SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.

Our Double-Strength SAMe 400 contains 400 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.

Double-Strength SAMe is sealed in blister packs for freshness and stability.

Suggested Use

Adult Use: Take 1 tablet daily away from food, or as recommended by a nutritionally-informed physician. Do not chew or crush tablet.

Other Ingredients

Cellulose, methacrylic acid copolymer, glyceryl behenate, magnesium silicate, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silicon dioxide, medium chain triglycerides, sodium carboxymethyl starch and iron oxide.

The SAMe found in Doctor's Best SAMe 400 mg (Double Strength) is free from yeast, dairy, gluten, soy, wheat and artificial flavoring.

Contains nothing other than listed ingredients

Warnings

Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.

Store product in a cool, dry place to ensure maximum quality.

Visit Manufacturer's Website
Supplement Facts
Serving Size: 1 tablet
Servings Per Container: 30 servings
  Amount per serving % Daily Value
S-Adenosyl Methionine (from 800 mg of SAMe tosylate disulfate) 400 mg
† Daily Value not established.

iHerb Customer Reviews

5 Stars
4 Stars
3 Stars
2 Stars
1 Stars
 

wonders!

Posted by 4993142139333910637 on May 05, 2016

I have jumopers knee and this thing is the only thing that helped. I have taken NSAIDs and they helped some what but the motility of my knee was always decreased. This thing helped me so much! It made my mood much better too! This is way better than MSM IMO!!

Was this review helpful to you?

Great product

Posted by 5443300568896328638 on Apr 01, 2016

It is very good product for improving liver function. I really happy to find it here. It helped me to eliminate bitterness in my mouth. I used it with r-lipoic acid and mega-pc and l-glutamin.

Was this review helpful to you?

Didn't work for me

Posted by 4846739210802950254 on Mar 21, 2016

Completely useless product.

Was this review helpful to you?

great

Posted by 5407946756973564481 on Jan 17, 2016

Wonderful product.. It really works and give me a great boost from the first day Highly recommend it

Was this review helpful to you?

Helps the Joints

Posted by Reviewer2860699 on Dec 13, 2015

As I get older, (65 ) my joints have been giving me some grief... not arthritis, just weak and aching. I have tried various remedies. After using SAMe for a month in a less potent formula (200 mg) I switched to this brand and 400 mg. After a few weeks, I noticed a definite improvement with joints aching less. As for any effects on mood... maybe there's a little less gloominess, but this is not so obvious.

Was this review helpful to you?

See All Reviews