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- Science-Based Nutrition
- Dietary Supplement with 400 mg Active S-Adenosyl Methionine Per Tablet
- Enhances Mood & Neural Function
- Promotes Joint Comfort & Mobility
- Supports Liver Health & Detoxification
- Pharmaceutical Grade
- Sealed in Blister Packs for Freshness & Convenience
- Suitable for Vegetarians
S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.
Supplementing with SAMe
The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market.
SAMe and Joint Function
SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.
SAMe and Neural Health
SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.
SAMe and Liver Function
SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.
Our Double-Strength SAMe 400 contains 400 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.
Double-Strength SAMe is sealed in blister packs for freshness and stability.
Adult Use: Take 1 tablet daily away from food, or as recommended by a nutritionally-informed physician. Do not chew or crush tablet.
Cellulose, methacrylic acid copolymer, glyceryl behenate, magnesium silicate, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silicon dioxide, medium chain triglycerides, sodium carboxymethyl starch and iron oxide.
The SAMe found in Doctor's Best SAMe 400 mg (Double Strength) is free from yeast, dairy, gluten, soy, wheat and artificial flavoring.
Contains nothing other than listed ingredients
Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.
Store product in a cool, dry place to ensure maximum quality.
|Serving Size: 1 tablet|
|Servings Per Container: 30 servings|
|Amount per serving||% Daily Value|
|S-Adenosyl Methionine (from 800 mg of SAMe tosylate disulfate)||400 mg||†|
|† Daily Value not established.|
Ahhh Found it !
Ahhh Found it !
I recently went off Prozac....I just slept All the time. I decided to try some Sam-e. Unfortunately, I tried three other brands before Doctor's best. The others made me sleep...I was neither happy or sad...just sleepy. Dr. Best was the only one that made me perk up and WANT to do things...I'm not exaggerating ...I guess everyone's brain is different and we all have different reactions . This one is the one for me...Finally I found my match. If I could give this product 6...8..20 stars...I would.
TALC is an ingredient!
TALC is an ingredient!
I have not used this product but I was ready to try it until I read all the ingredients listed. There are numerous chemicals including TALC which is a known carcinogen. I have contacted the Dr. Best company and waiting to hear back from them. The ingredients listed as "other" do not appear safe and I would be very concerned about ingesting these. It's a joke that one would trade off one problem for another like, cancer or liver toxicity.
Posted by 5530564982578978936 on Jan 19, 2017
Has made a difference for me, although have to admit that it is very pricey
Posted by Reviewer1986419 on Jan 05, 2017
Hi, I have only just received this product a couple of days ago, so I can't really comment yet, but if it is as good as they say, health wise it is going to make a big difference to me. I will do another review over time if I notice any change in my health? Regards, Colleen Faed, Mandurah, Western Australia.
Posted by 4901901375085070023 on Dec 18, 2016
This product seems to make your mood very grumpy. I have not felt like this, very annoyed and aggrevated but as soon as stop taking it my mood changes back to more relaxed and able to feel like going with the flow . I have changed to taking it just before bed and this is better.
What a relief!
Posted by 4679482629534230584 on Dec 12, 2016
Thank goodness for this product! Helps to relieve my symptoms of depression and anxiety. In my case, I didn't need to go onto medication as this product helped so much!