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Doctor's Best, SAM-e (S-Adenosyl-L-Methionine) 400, Double-Strength, 60 Enteric Coated Tablets

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$33.33 (46)
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In Stock
  • Expiration Date: Feb 2019
  • Shipping Weight: 0.41 lbs (0.19 kg)
  • Product Code: DRB-00252
  • UPC Code: 753950002524
  • Package Quantity: 60 Enteric Coated Tablets
  • Dimensions: 6.3 x 3.3 x 2 in, 0.25 lbs (0.11 kg)
Product Overview


  • Science-Based Nutrition
  • Dietary Supplement with 400 mg Active S-Adenosyl Methionine Per Tablet
  • Enhances Mood & Neural Function
  • Promotes Joint Comfort & Mobility
  • Supports Liver Health & Detoxification
  • Pharmaceutical Grade
  • Sealed in Blister Packs for Freshness & Convenience
  • Suitable for Vegetarians

S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.

Supplementing with SAMe

The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market.

SAMe and Joint Function

SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.

SAMe and Neural Health

SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.

SAMe and Liver Function

SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver production. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.

Our Double-Strength SAMe 400 contains 400 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.

Double Strength SAMe is sealed in blister packs for freshness and stability.

Suggested Use

Adult Use: Take 1 tablet daily away from food, or as recommended by a nutritionally-informed physician. Do not chew or crush tablet.

Other Ingredients

Cellulose, methacrylic acid copolymer, glyceryl behenate, magnesium silicate, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silicon dioxide, medium chain triglycerides, sodium carboxymethyl starch and iron oxide.

The SAMe found in Doctor's Best SAMe 400 mg (Double Strength) is free from yeast, dairy, gluten, soy, wheat and artificial flavoring

Contains nothing other than listed ingredients.


Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.

Store product in a cool, dry place to ensure maximum quality.

Supplement Facts
Serving Size: 1 tablet
Servings Per Container: 60 servings
  Amount per serving % Daily Value
S-Adenosyl Methionine (from 800 mg SAM-e tosylate disulfate) 400 mg
† Daily Value not established.
iHerb Customer Reviews


Posted by 5291689150363736372 on Oct 11, 2016

My natural path told me to get this about 6 months ago & it's turned my life around! I've lost a ton of weight, look awesome, my moods WAY more positive, and in general I feel clearer and cleaner, not to mention my joints are WAY more flexible! Going to take this for the rest of my life :)

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Posted by Reviewer1750949 on Sep 15, 2016

Top quality product

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Wouldn't Be Without It!

Posted by 4661612049711642735 on Aug 28, 2016

I suffer from clinical depression, and this product has made a huge difference to my quality of life. My doctor recommended this brand because of its enteric coating, and iHerb's price makes it a lot more affordable. Started with the regular strength for a few months before going up to this higher dose. Can't recommend it highly enough!

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reducing pain for osteoarthritis

Posted by 5126774275656549311 on Aug 27, 2016

After just one week I could feel a significant reduction in my constant pain. I am looking forward to no pain within a month.

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Great price and product

Posted by 4680988612310580849 on Aug 21, 2016

This product is so affordably priced compared to the others, and has consistently been excellent quality. Really helps with energy levels and lifting mood. My only complaint is that about every ten boxes or so, one card might be missing an end capsule presumably where the machine fails to drop one in... otherwise, no complaints =)

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