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Doctor's Best, SAM-e (S-Adenosyl-L-Methionine) 400, Double-Strength, 60 Enteric Coated Tablets

By Doctor's Best

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In Stock
  • Product Code: DRB-00252
  • UPC Code: 753950002524
  • Package Quantity: 60 Enteric Coated Tablets
  • Dimensions: 6.3 x 3.3 x 2 in, 0.25 lbs (0.11 kg)

Product Overview

  • Science-Based Nutrition
  • Dietary Supplement with 400 mg Active S-Adenosyl Methionine Per Tablet
  • Enhances Mood & Neural Function
  • Promotes Joint Comfort & Mobility
  • Supports Liver Health & Detoxification
  • Pharmaceutical Grade
  • Sealed in Blister Packs for Freshness & Convenience
  • Suitable for Vegetarians

S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.

Supplementing with SAMe

The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market.

SAMe and Joint Function

SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.

SAMe and Neural Health

SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.

SAMe and Liver Function

SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver production. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.

Our Double-Strength SAMe 400 contains 400 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.

Double Strength SAMe is sealed in blister packs for freshness and stability.

Suggested Use

Adult Use: Take 1 tablet daily away from food, or as recommended by a nutritionally-informed physician. Do not chew or crush tablet.

Other Ingredients

Cellulose, methacrylic acid copolymer, glyceryl behenate, magnesium silicate, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silicon dioxide, medium chain triglycerides, sodium carboxymethyl starch and iron oxide.

The SAMe found in Doctor's Best SAMe 400 mg (Double Strength) is free from yeast, dairy, gluten, soy, wheat and artificial flavoring

Contains nothing other than listed ingredients.


Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.

Store product in a cool, dry place to ensure maximum quality.

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Supplement Facts
Serving Size: 1 tablet
Servings Per Container: 60 servings
  Amount per serving % Daily Value
S-Adenosyl Methionine (from 800 mg SAM-e tosylate disulfate) 400 mg
† Daily Value not established.

iHerb Customer Reviews

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1 Stars

Made a world off difference - saved my sanity.

Posted by Reviewer2680726 on Jan 06, 2012

I can see now that I was quite depressed - too depressed and demotivated to get myself to a doctor. Luckily I read about SamE and started taking it. I feel like a different person - I am happy, motivated and energetic - the total opposite of what I was a month ago. Noticed it working after about 1 week-10 days. I take 1 tablet 1/2 hr before food in the morning. I wholeheartedly recommend it. Iherbs price is great and so is their service - just don't try airmail to Australia - I have done that before and it takes weeks...

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21 people found the following review helpful

excellent sleep aid

Posted by Reviewer1799983 on Dec 29, 2011

This amino acid really is helpful when it comes to sleep. I take two of these about one hour before I plan to fall asleep. In our family we all have problems with anxiety, which interferes with sleep. I now fall asleep and stay asleep all night long. Highly recommended!I also take one mg of melatonin, as well.

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15 people found the following review helpful

Works! Lift's your mood and takes away joint and back pain.

Posted by Reviewer1767397 on Oct 20, 2011

I ordered Doctor's Best SAM-e 400 mg at iHerb for delivery to Sweden, cause you can't get it here. I take it against lower back pain and affective seasonal disorder (cause it get's very dark here in northern Europe in winter, for long and cold 7 months!). It works very good, joints are aching much less and my mood is really good. SAM-e is wonderful stuff and I recommend it strongly.

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11 people found the following review helpful

SAM-e for joints and mood

Posted by Reviewer1134057 on Oct 25, 2011

This SAM-e is great for joint mobility and mood. I have recently read that it might be better for me to take a 200mg twice a day as opposed to taking a 400mg once per day. I will try that next time I order.

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11 people found the following review helpful

DB sam-e

Posted by Reviewer1034669 on Jun 24, 2011

I have been using this product for a couple of years now. I have mild depression that can affect my mood if left untreated. I tried taking prescription antidepressants but it just seemed like too much. Also, both separate times I took prescriptions my male pattern balding went on overdrive. Sam-e gives me just the amount of mood boost I need and doesn't make my hair fall out. Win-win. This brand has always been the least expensive and it works well.

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8 people found the following review helpful

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