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- Science-Based Nutrition
- Dietary Supplement with 400 mg Active S-Adenosyl Methionine Per Tablet
- Enhances Mood & Neural Function
- Promotes Joint Comfort & Mobility
- Supports Liver Health & Detoxification
- Pharmaceutical Grade
- Sealed in Blister Packs for Freshness & Convenience
- Suitable for Vegetarians
S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.
Supplementing with SAMe
The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market.
SAMe and Joint Function
SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.
SAMe and Neural Health
SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.
SAMe and Liver Function
SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver production. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.
Our Double-Strength SAMe 400 contains 400 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.
Double Strength SAMe is sealed in blister packs for freshness and stability.
Adult Use: Take 1 tablet daily away from food, or as recommended by a nutritionally-informed physician. Do not chew or crush tablet.
Cellulose, methacrylic acid copolymer, glyceryl behenate, magnesium silicate, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silicon dioxide, medium chain triglycerides, sodium carboxymethyl starch and iron oxide.
The SAMe found in Doctor's Best SAMe 400 mg (Double Strength) is free from yeast, dairy, gluten, soy, wheat and artificial flavoring
Contains nothing other than listed ingredients.
Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.
Store product in a cool, dry place to ensure maximum quality.
|Serving Size: 1 tablet|
|Servings Per Container: 60 servings|
|Amount per serving||% Daily Value|
|S-Adenosyl Methionine (from 800 mg SAM-e tosylate disulfate)||400 mg||†|
|† Daily Value not established.|
I can see now that I was quite depressed - too depressed and demotivated to get myself to a doctor. Luckily I read about SamE and started taking it. I feel like a different person - I am happy, motivated and energetic - the total opposite of what I was a month ago. Noticed it working after about 1 week-10 days. I take 1 tablet 1/2 hr before food in the morning. I wholeheartedly recommend it. Iherbs price is great and so is their service - just don't try airmail to Australia - I have done that before and it takes weeks...
This amino acid really is helpful when it comes to sleep. I take two of these about one hour before I plan to fall asleep. In our family we all have problems with anxiety, which interferes with sleep. I now fall asleep and stay asleep all night long. Highly recommended!I also take one mg of melatonin, as well.
It helps with anxiety and depressive mood
Posted by Reviewer1213286 on Nov 30, 2016
By taking this product, 2 per day, feeling a lot relax and better mood. Result will show in around two weeks. By taking 3 pills a day, will feel super relax. It works very well on anxiety disorder.
Posted by 4831599994561862109 on Nov 29, 2016
I have hetero mthfr cbs mutation and this took care of my mood and bodyaches. The dosage and strength is just right. I cant live without these. Literally. This is a lifelong support for mthfr mutant. The best SAMe ive had so far.
Posted by 5291689150363736372 on Oct 11, 2016
My natural path told me to get this about 6 months ago & it's turned my life around! I've lost a ton of weight, look awesome, my moods WAY more positive, and in general I feel clearer and cleaner, not to mention my joints are WAY more flexible! Going to take this for the rest of my life :)
Posted by Reviewer1750949 on Sep 15, 2016
Top quality product
Wouldn't Be Without It!
Posted by 4661612049711642735 on Aug 28, 2016
I suffer from clinical depression, and this product has made a huge difference to my quality of life. My doctor recommended this brand because of its enteric coating, and iHerb's price makes it a lot more affordable. Started with the regular strength for a few months before going up to this higher dose. Can't recommend it highly enough!