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Doctor's Best, SAM-e (S-Adenosyl-L-Methionine) 400, Double-Strength, 60 Enteric Coated Tablets

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  • Product Code: DRB-00252
  • UPC Code: 753950002524
  • Package Quantity: 60 Enteric Coated Tablets
  • Dimensions: 6.3 x 3.3 x 2 in, 0.25 lbs (0.11 kg)
Product Overview


  • Science-Based Nutrition
  • Dietary Supplement with 400 mg Active S-Adenosyl Methionine Per Tablet
  • Enhances Mood & Neural Function
  • Promotes Joint Comfort & Mobility
  • Supports Liver Health & Detoxification
  • Pharmaceutical Grade
  • Sealed in Blister Packs for Freshness & Convenience
  • Suitable for Vegetarians

S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.

Supplementing with SAMe

The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market.

SAMe and Joint Function

SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.

SAMe and Neural Health

SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.

SAMe and Liver Function

SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver production. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.

Our Double-Strength SAMe 400 contains 400 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.

Double Strength SAMe is sealed in blister packs for freshness and stability.

Suggested Use

Adult Use: Take 1 tablet daily away from food, or as recommended by a nutritionally-informed physician. Do not chew or crush tablet.

Other Ingredients

Cellulose, methacrylic acid copolymer, glyceryl behenate, magnesium silicate, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silicon dioxide, medium chain triglycerides, sodium carboxymethyl starch and iron oxide.

The SAMe found in Doctor's Best SAMe 400 mg (Double Strength) is free from yeast, dairy, gluten, soy, wheat and artificial flavoring

Contains nothing other than listed ingredients.


Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.

Store product in a cool, dry place to ensure maximum quality.

Supplement Facts
Serving Size: 1 tablet
Servings Per Container: 60 servings
  Amount per serving % Daily Value
S-Adenosyl Methionine (from 800 mg SAM-e tosylate disulfate) 400 mg
† Daily Value not established.
iHerb Customer Reviews

Great Product

Posted by 4612781982530537139 on Jul 12, 2016

This actually works. It has a calming effect. Highly recommended.

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Great dose

Posted by plantbadedelixir on Jun 25, 2016

Great dose, need to be on it longer before I can decide if I feel anything from it. Vegan.

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I have found this to be a great product

Posted by 4614306250807840528 on Jun 03, 2016

I have been using this product for at least 12 months now. I have found the dosage that works best for me, through consultation with my doctor. I am very pleased with the results I have obtained. My quality of health is better I believe as a result of using Sam e. I use it in combination with a vitamin B complex.

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Very noticable results.

Posted by 5551401762726876213 on May 29, 2016

I have a 14 year old English Staffordshire Bull Terrier (dog) who over the past 2 1/2 years has started to develop arthritis in her back hips. Just over a year ago she went to the vet for a 'general check-up', a part of this 'check-up' involved a complete 'blood work' to check how her internal organs were going. Cut a long story short the blood tests revealed that my dog had a 'high count' come back on her liver. After having an ultra sound & a high definition scan the results ,thankfully ruled out cancer. My vet said that there was a (expensive) medication that she could prescribe for my dog in order to lower the levels shown in the blood test ( normal count is between 100 -150 , my dogs liver count was 668 ! )or I could try SAMe tablets. One 400mg tablet a day on an empty stomach. Within 3-5 days there was a marked increase in my dogs general alertness and also a marked improvement in her walking (movement in her back legs/hips). I returned to the vet after 3 months , as requested, to have a repeat blood count done on my dog ....and the count had dropped from 668 to 609 . Every 3 months since then the blood count has continued to drop (currently around 390 -still high ,but it is improving). The affects that her arthritis has had on her has also significantly been reduced. She is a 14 year old dog who since being on the SAMe tablets is now getting around like an 8yo ! I have heard of people saying that they have had great results from taking SAMe ...well I can't comment on the 'human' side of things but I can and will highly recommend it for any dog owner whose dog is having trouble with arthritis , liver trouble or neuro problems related to old age.

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great product

Posted by 5301095804449401452 on May 21, 2016

For those who don't methylate properly this product is great for people with allergies.

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