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Jarrow Formulas, Natural SAM-e (S-Adenosyl-L-Methionine) 200, 200 mg, 60 Tablets

By Jarrow Formulas

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In Stock
  • Product Code: JRW-20016
  • UPC Code: 790011200161
  • Package Quantity: 60 Tablets
  • Dimensions: 6.2 x 3.3 x 1.9 in, 0.15 lbs (0.07 kg)

Product Overview

  • Full Potency
  • In Foil Blister Pack
  • S-Adenosyl Methionine
  • 200 mg (Net Yield) SAM-e from 400 mg SAM-e Tosylate Disulfate
  • Highest Concentration of Active S,S Form
  • Enteric-Coated Tablets
  • Net Yield
  • Gluten-Free
  • Vegan
  • Dietary Supplement
  • Suitable for Vegetarians/Vegans


  • Joint Strength
  • Liver Detoxification
  • Mood and Brain Function

Jarrow Formulas SAM-e 200 provides a full 200 mg SAM-e (net yield) from 400 mg of SAM-e tosylate disulfate. SAM-e 200 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.

Contains More of the Active S,S Form

Found in all living cells, SAM-e is a metabolite of methionine (an essential amino acid). SAM-e is a chiral molecule and consists of two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas SAM-e is made naturally by microbiological fermentation and then specially processed without solvents to preserve 68-80% (S,S) SAM-e, the highest active level available.

SAM-e has been clinically shown to have the following benefits:

Joint Strength

SAM-e supports the production of healthy connective tissue through transulfuration. In this process, critical components of connective tissue, including glucosamine and the chondroitin sulfates, are sulfated by SAM-e metabolites.

Brain Metabolism

SAM-e methylation reactions are involved in the synthesis of neurotransmitters such as L-DOPA, dopamine and related hormones, serotonin, epinephrine and phosphatidylcholine (a component of lecithin).


SAM-e metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase and glutathione-S-transferase), which are substances important for liver function, including phase II detoxification.

Full Potency 200 mg SAM-e is derived from 400 mg of SAM-e tosylate disulfate.

Suggested Use

Take 1 tablet 1 or 2 times per day on an empty stomach or as directed by your qualified healthcare professional.

For best result, use with Jarrow Formulas JarroSil, the biologically Activated Silicon.

Other Ingredients

Cellulose, mannitol, glycerol behenate, magnesium stearate (vegetable source), silicon dioxide, sodium starch glycolate, enteric coating (methacrylate copolymers), magnesium silicate, titanium dioxide, triethyl citrate, silicon dioxide and riboflavin.

No wheat, no gluten, no soybeans, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts


Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using. Individuals with Parkinson’s disease, bi-polar disorder or manic depression should not use SAM-e. Do not use if pregnant or nursing. Do not exceed recommended intake. May cause gastrointestinal upset in some persons. If you experience discomfort, discontinue use.

Jarrow Formulas Sam-e 200 is foil blister-packed to maximize stability and safety. Do not use if outer seal or blister pack is broken.

Store in a cool, dry place.

Keep out of the reach of children.

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Supplement Facts
Serving Size: 1 Tablet
Servings Per Container: 60
  Amount Per Serving % DV
S-Adenosyl Methionine (from 400 mg of SAM-e tosylate disulfate) 200 mg *
* Daily Value not established.

iHerb Customer Reviews

5 Stars
4 Stars
3 Stars
2 Stars
1 Stars

Kicked me off my feet! Go SLOW with this.

Posted by Reviewer1704933 on Apr 05, 2008

While I know that SAMe is wonderful...I took one of these and aprox. 5 hours later I was having horrific heart palpitations,dizziness,anxiety, pounding heart rate and panic attacks. The effects lasted several days. I was told by someone very knowledgable that this could mean that I may be very deficient of SAMe, which would explain my reaction. I just don't know if I could go through that again! He suggested to titrate slowly. I know I am an over methylator, this added to the intense reaction. Just be very careful. If you are sensitive go very low doses to begin with. I should have tried 25mg to start. It doesn't say potent for nothing! I love Jarrow products. I am still giving this 5 stars. My reaction by no means speaks poorly about the product itself.

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23 people found the following review helpful

Works excellent as mood enhancer

Posted by Reviewer1160172 on Nov 18, 2007

I'm taking Jarrow Formulas, SAM-e 200 for the last 3 years and it is contunuing do deliver on tbe promise to help enhance my mood. The quality of this product is excellent, I can feel the difference.

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7 people found the following review helpful

SUPER! Depressed hubby feels better

Posted by Reviewer1521392 on Apr 17, 2009

My depressed hubby is feeling much happier and in lighter much more fun spirits and more like he normally is....no jolty weird stuff, he just said I feel good, not depressed...hes laughing and acting crazy as usual...when he is not depressed...will use for a long time!

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7 people found the following review helpful

Effective in the management of prolactin

Posted by Reviewer1492376 on Sep 22, 2009

I started to take this for hyperprolactinemia as I read some research that claimed that SAM-e acted as a dopamine agonist. I put it to the test to see if it would affect the levels of prolactin in my blood. After six months of taking just one tablet per day my prolactin level has stabilised. I'm now taking 2 tablets per day and in six months time I will have more blood tests to see if levels have decreased. I stopped taking medication for this condition 10 months ago. Not only does it appear to be helping to manage prolactin I feel really good on it as there are so many other benefits including mood enhancement and liver detox. Definitely the right supplement for me! I also take an Agnus Castus tincture to manage prolactin

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6 people found the following review helpful

Good quality!

Posted by Reviewer2507624 on Oct 15, 2008

SAMe has greatly helped me with my back pains (I practically have no more pain), with my liver and my mood. However, if I take too much of SAMe for a long time, my mind gets too excited (I think too much and I do not sleep very well).

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4 people found the following review helpful

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