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Jarrow Formulas, Natural SAM-e (S-Adenosyl-L-Methionine) 400, 400 mg, 30 Enteric-Coated Tablets

By Jarrow Formulas

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In Stock
  • Product Code: JRW-20020
  • UPC Code: 790011200208
  • Package Quantity: 30 Enteric-Coated Tablets
  • Dimensions: 1.8 x 3.1 x 5 in, 0.15 lbs (0.07 kg)

Product Overview

  • Pharmaceutical Grade, Stabilized
  • Full Potency
  • S-Adenosyl Methionine
  • 400 mg (Net Yield) SAM-e from 800 mg SAM-e Tosylate Disulfate
  • Highest Concentration of Active S, S Form
  • 30 Count
  • In Foil Blister Pack
  • Vegan
  • Gluten Free
  • Dietary Supplement


  • Longevity
  • Joint Strength
  • Liver Detoxification
  • Mood and Brain Function

Jarrow Formulas SAM-e 400 provides a full 400 mg SAM-e (net yield) from 800 mg of SAM-e tosylate disulfate. SAM-e 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.

Contains More of the Active S,S Form

Found in all living cells, SAM-e is a metabolite of methionine (an essential amino acid). SAM-e is a chiral molecule and consists of two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas SAM-e is made naturally by microbiological fermentation and then specially processed without solvents to preserve 68-80% (S,S) SAM-e, the highest active level available.

SAM-e has been clinically shown to have the following benefits:

Joint Strength

SAM-e supports the production of healthy connective tissues through transulfuration. In this process, critical components of connective tissue, including glucosamine and the chondroitin sulfates, are sulfated by SAM-e metabolites.

Brain Metabolism

SAM-e methylation reactions are involved in the synthesis of neurotransmitters such as L-DOPA, dopamine and related hormones, serotonin, epinephrine and phosphatidylcholine (a component of lecithin).


Methylation of DNA appears to be important in the suppression of errors in DNA replication. Demethylation of DNA is considered a contributor to the aging process. Proper methylation through substances such as SAM-e positively influences longevity.


SAM-e metabolism supports the synthesis of glutathione (GSH) and glutathione - dependent enzymes (glutathione peroxidase and glutathione - S- transferase), which are substances important for liver function.

Suggested Use

Take 1 tablet per day on an empty stomach, or as directed by your qualified health care consultant.

For best result, use with Jarrow Formulas JarroSil, the biologically Activated Silicon.

Other Ingredients

Cellulose, mannitol, glyceryl behenate, magnesium stearate (vegetable source), silicon dioxide, sodium starch, glycolate, enteric coating (methacrylate copolymers), magnesium silicate, titanium dioxide, triethyl citrate, and riboflavin.

Suitable for vegetarians/vegans

No wheat, no gluten, no soybeans, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts

Full Potency 400 mg SAM-e is derived from 800 mg of SAM-e tosylate disulfate.


Individual using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRI) and MAO Inhibitors should consult a physician before using. Individuals with Parkinson's disease, bi-polar disorder or manic depression should not use SAM-e.

This product complies with the proposed USP Monograph for SAM-e.

Jarrow Formulas Sam-e 400 is foil blister-packed to maximize stability and safety. Do not use if outer seal of blister pack is broken.

Store in a cool, dry place.

Keep out of the reach of children.

Visit Manufacturer's Website
Supplement Facts
Serving Size: 1 Tablet
Servings Per Container: 30
 Amount Per Tablet%DV
S-Adenosyl Methionine (from 800 mg of SAM-e tosylate disulfate) 400 mg *
* Daily Value not established.

iHerb Customer Reviews

5 Stars
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1 Stars

Great quality

Posted by 5563996035167001097 on Oct 21, 2015

I started taking SAM-e as i had read it helps with depression. Not only has it helped, i sleep better at night :)

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This works.

Posted by 4766872620965520922 on Jun 09, 2015

I have used prescription antidepressants for years and have chosen to stop taking them. After a few months I became quite 'blue', easily upset and intraverted. I have found this product to help a great deal. I take one in the morning and in the afternoon I take one of Doctor's Best Best D-Phenylalanine 500mg tablets. I am way less tearfull and in a much better mood from day to day. I feel much more like my old self. Thank you iherb for a brilliant variety of excellent products as well as excellent delivery to New Zealand.

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Posted by 5298886912521585806 on Jan 24, 2015

excellent for depression taking one tablet half hour before food.

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Peace of Mind

Posted by 4914116887331997861 on Jan 12, 2015

Not all SAM-e products will work as effectively for each person. So sometimes you can purchase a brand that seems not to work, this is worthwhile to note. The Jarrow Formulas 400mg works well for me. Easily to swallow tablet, I take one first thing in the morning and 1 at bedtime for anxiety/depression related issues. Definitely hands down works for me. Don't forget to take a Vitamin B and Folate in the day time also. If this review was helpful, please like the post.

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Too bad for anxiety

Posted by 5741836419234565606 on Jan 11, 2015

Sam E may work for depression but I couldn't even try that longer since its immediate side effect is a sudden rise in anxiety level which is extremely uncomfortable than depression itself. May be 400 MG is too strong for me but still I don't want to try anything which worsen anxiety.

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