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- Foundation for Longer Life
- Pyrroloquinoline Quinone
- Supports Optimal Mitochondrial Biogenesis and Function
- Dietary Supplement
Mitochondrial Energy Optimizer with BioPQQ
All cells in our bodies contain tiny organelles called mitochondria that function to produce cellular energy by means of the adenosine triphosphate (ATP) cycle. The number of mitochondria in a cell varies widely by organism and by tissue type. A human cell can have from a few to several thousand mitochondria.
One of the most serious events that cause the loss of cellular vitality is the depletion of mitochondrial energy-producing function. Cells require healthy mitochondrial activity to perform life-sustaining metabolic processes. As mitochondrial function weakens in our cells, so does the vitality of organs such as the heart and brain or in some cases, the entire body.
In order for the mitochondria to create the energy needed to sustain cellular function, fatty acids (which serve as the mitochondria's fuel) must be transported through the cell membrane and into the mitochondria.
Life Extension members now have access to a state-of-the-art nutritional formula called Mitochondrial Energy Optimizer with BioPQQ that not only protects delicate cellular structures and enables cells to perform life-sustaining metabolic processes . . . it also helps generate new mitochondria. This formula is designed to counteract age-related structural and functional changes and promote biogenesis with these unique ingredients:
PQQ (Pyrroloquinoline quinone) — this next generation cellular rejuvenator triggers growth of new mitochondria in aging cells and activates genes involved in protecting delicate structures within the mitochondria.Carnosine — As humans age, their proteins become irreversibly damaged by glycation reactions. Glycation is the cross-linking of proteins or lipids and sugar to form non-functioning advanced glycation end-products (AGEs) in the body, which can lead to alterations of normal cell function. Carnosine is not only the premier antiglycating agent, but it also protects neurons against reactive and cytotoxic protein carbonyl species associated with normal aging.
Luteolin — Unremitting systemic inflammation is involved with virtually every undesirable consequence of aging. Culprits behind inflammatory reactions are pro-inflammatory cytokines, such as interleukin-1 and tumor necrosis factor alpha. Luteolin is a super-potent plant extract that has been shown to suppress these inflammatory cytokines.
Benfotiamine — Benfotiamine blocks multiple destructive biochemical pathways, including AGEs' formation pathway, which is induced by higher than desirable blood glucose levels. Human mortality studies indicate that ideal fasting glucose levels are between 74–85 mg/dL. Yet many aging people have fasting glucose above 90 mg/dL, which is less than optimal. Benfotiamine can activate glucose metabolism and promote already healthy blood glucose levels already within normal range. In addition, benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage.
Pyridoxal 5'-Phosphate — Aging results in the formation of toxic advanced glycation end products throughout the body. Pyridoxal 5'-phosphate is the active form of vitamin B6 that has been shown to protect against both lipid and protein glycation reactions.
R-Lipoic Acid — Free radical activity in the mitochondria plays a major role in the loss of cellular vitality. The microencapsulated Bio-Enhanced R-lipoic acid facilitates youthful mitochondrial energy output while guarding against free radicals. Two forms of lipoic acid are sold on the supplement market, but R-lipoic acid is far more potent.
Acetyl-L-Carnitine Arginate — The amino acid L-carnitine is required to transport fats into the mitochondria to be burned for cellular energy. ArginoCarn Acetyl-L-carnitine arginate is a patented form of carnitine that has been shown in cell cultures to stimulate the growth of neurites.
Read the entire label and follow the directions carefully prior to use.
Take two (2) capsules twice daily, preferably early in the day or all at once upon wakening, or as recommended by a healthcare practitioner. This product can be taken with or without food. Refrigerate after opening.
Vegetable cellulose (capsule), microcrystalline cellulose, vegetable stearate, silica, candelilla wax, beeswax, calcium silicate.
- Keep out of reach of children.
- Do not exceed recommended dose.
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
|Serving Size: 4 Capsules|
|Serving Per Container: 30|
|Amount Per Serving||% Daily Value|
|Vitamin B6 (as pyridoxal 5'-phosphate)||100 mg||5000%|
|Calcium (as calcium carbonate)||230 mg||23%|
|ArginoCarn Acetyl-L-carnitine arginate dihydrochloride||675 mg||**|
|R-Lipoic Acid (as microencapsulated
Bio-Enhanced stabilized Na-RALA sodium R-lipoate)
|BioPQQ Pyrroloquinoline quinone disodium salt||10 mg||**|
|Luteolin [from Pureolin and SMART (cynara cardunculus) extract (leaf)]||8 mg||**|
|**Daily value not established|
Some people feel a lot from PQQ (I certainly do feel it) and some people feel absolutely nothing. When I take PQQ (alone or as a part of this formula) I feel that my body heats up, I have more energy and I get a lot less hungry, sometimes to the point where I forget to eat. It helps me with my diet. Mitochondrial Energy Optimizer with BioPQQ from Life Extension is a complete supplement which targets mitochondria, the powerhouse of the cell. Some people recommend taking Ubiquinol together with PQQ, it seems to improve memory. Obesity is a complicated health problem and nobody knows the true causes. Some experts believe that obesity appears because of unhealthy mitochondria - they can't turn fats into energy and so people feel hungry all the time and have difficulties burning fat. Supplements that target mitochondria, such as PQQ, Acetyl-L-Carnitine, Alpha-Lipoic-Acid, Ubiquinol, Idebenone, MitoQ, Resveratrol can fix this problem and make it easier to lose weight. For more information, please look up "mitochondrial hypothesis of obesity". PQQ is also reported to help increase athletic endurance - it helps you go on and on and on. I have also felt this effect. PQQ may also help improve non-alcoholic fatty liver disease or NASH, as mitochondria play an important role in these liver diseases. The correct dosage for PQQ seems to be 20 mg - 60 mg per day. This is why, together with this excellent formula from LEF, I also take some pure PQQ from Jarrow.
I only take took it for a week now and I can definitely say it works : more energy, better skin, improved musculation, clearer thinking. I usually over-react on medication and it was the case with this product : taking more than one pill a day makes me jittery and and I have heart palpitation. I am not heavy (60kg) and it may be an explanation. Well anyway I take one pill and it is fine for me. Plus the box will last longer! Edit : I have tried every component individually to be sure and it appears that I have an allergy to R lipoic acid. It is common actually. The very good ingredients are Vitamin B6 (as pyridoxal 5'-phosphate) and Pqq. I will finish the bottle and take complements individually. I leave 5 stars because I do believe the product is very good in spite of my bad reaction.
Posted by Reviewer2967632 on Dec 13, 2015
Posted by 5552266117756560494 on Apr 03, 2015
Posted by Reviewer2666562 on Mar 09, 2015
Research shows that this supplement helps age-related energy issues. The addition of PQQ actually helps increase the number of mitochondria in the cells.
amazing right out of the gate
Posted by 4759933475879321928 on Aug 04, 2014
I bought this to enhance my mitochondrial functioning, which was rock-bottom (according to naturopath). I have major energy issues. This was a step in the larger goal of getting pregnant. PQQ is supposed to enhance egg health. I started with 1 or 2 a day, and noticed an nice increase in energy - a low buzz that was unlike caffeine. I just felt...good. I could keep going even past 7pm. Amazing! I was only able to take these for about 1.5 weeks, however, as I found out I am pregnant! I have no idea if they contributed to the success, but I now have stopped them because there's no research on the ingredients' usage during pregnancy. A part of me is sad I didn't get to enjoy the benefits for longer. A week or so later, I am now starting to feel the 1st trimester fatigue and it kills me that I can't take these! I fully intend to order another bottle when I'm through breastfeeding, and in the meantime I've started my husband on them.
Mitochjondrial energy optimizer
Posted by 5719297981995924070 on Jul 14, 2014
This product gives me energy. If I don't take it, I have that tired and dragging feeling all day long. Better than Ribose when you suffer from statin toxicity.