Life Extension, Optimized Folate (L-Methylfolate), 1000 mcg, 100 Veggie Caps (Discontinued Item)
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- For Longer Life
- Metabolically Active Form of Folic Acid
- Dietary Supplement
Optimized Folate (L-Methylfolate)
Folate is involved in neurotransmitter synthesis and critical enzymatic reactions throughout the body. By depleting excess homocysteine, folate benefits cardiovascular health and nervous system function.
Those who take ordinary folate supplements, however, may not be experiencing its full spectrum of effects. This is because once ingested, not everyone converts folate to its biologically active form called 5-methyltetrahydrofolate (5-MTHF).Research shows that in a large proportion of the population, genetic enzyme deficiencies prevent the conversion of folate to 5-MTHF, leaving many vulnerable to low blood folate levels (and higher than desired homocysteine).
A more useful approach is to take the bioactive folate 5-MTHF directly, which has been declassified as a drug and is now available as a dietary supplement. 5-MTHF has been shown to dramatically raise red blood cell folate concentration, an indicator of folate status compared with folic acid supplementation. This bioactive folate is up to seven times more bioavailable than folic acid. This greater bioavailability is especially important in people who have a genetic enzyme deficiency since it requires no conversion to become metabolically active.
A study of 10 patients with endothelial dysfunction showed complete reversal of endothelial impairment after 5-MTHF supplementation compared with healthy control patients.
People with elevated homocysteine levels have a greater risk of cognitive decline. Unlike folic acid, 5-MTHF is able to cross the blood-brain barrier, which is especially important for people with cognitive difficulties to enhance the synthesis of acetylcholine in the brain — the neurotransmitter associated with memory.
Studies also show that the effectiveness of 5-MTHF can be further enhanced by co-supplementing with methylcobalamin (the active form of vitamin B12), vitamin B6, and riboflavin.
Read the entire label and follow directions carefully prior to use.
Take one (1) capsule daily with food, or as recommended by a healthcare practitioner.
Microcrystalline cellulose, vegetable cellulose (capsule), silica, vegetable stearate.
This product contains no milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, corn, or rice. Contains no sugar, and no artificial sweeteners, flavors, colors, or preservatives.
- Keep out of reach of children.
- Do not exceed recommended dose.
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Store tightly closed in a cool, dry place.
|Serving Size: 1 Vegetarian Capsule|
|Amount per Serving||% Daily Value|
|Folate [as (6S)-5-Methyltetrahydrofolic acid, glucosamine salt]||1000 mcg||250%|
iHerb Customer Reviews
This plus magnesium orotate has helped immensely with my problems with fatigue. After my doctor said she had no more ideas as to how to help with fatigue she suggested I might have chronic fatigue syndrome. I did some research and found that the protocol of these two supplements were supposed to help. To my amazement, they've helped me. Because of the cost I tried to stop taking them but found that my fatigue returned, which convinced me these supplements work.
I have been taking this supplement for a few weeks and I am pleased with the results. My doctor said all my blood work looks good and my pregnancy is healthy so far! I have a genetic mutation that prohibits my body from processing folic acid properly, so it is very important that I take a bioavailable form of folate to supplement my diet to help decrease the risks of abnormalities developing during early pregnancy.
Bring it Back - Please!
Posted by 4817100915545114109 on Apr 28, 2015
"Out of Stock - Discontinued". Why? This is an excellent product and needs to be brought back. LEF still makes it.
Posted by Reviewer2158100 on Sep 29, 2014
Love this product Folate is in the Methly form which is more readily bio available to the body......have been using PureInnovations product but think I will stick with this one.....
Life Extension, Optimized Folate (L-Methylfolate), 1000 mcg, 100 Veggie Caps (LEX-14391)
Posted by 5601616459809999204 on Jul 28, 2014
I have MS and this combined with some other vitamins seems to be helping
Haven't see effect, should be good
Posted by 4679907168970901982 on May 06, 2014
Haven't see effect, should be good