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Life Extension, Optimized Folate (L-Methylfolate), 1000 mcg, 100 Veggie Caps (Discontinued Item)

By Life Extension

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The item is currently out of stock and replenishment is unconfirmed.

Out of Stock - Discontinued
  • Product Code: LEX-14391
  • UPC Code: 737870143918
  • Package Quantity: 100 Veggie Caps
  • Dimensions: 3.7 x 2 x 2 in, 0.15 lbs (0.07 kg)

Product Overview

  • For Longer Life
  • Metabolically Active Form of Folic Acid
  • Dietary Supplement

Optimized Folate (L-Methylfolate)

Folate is involved in neurotransmitter synthesis and critical enzymatic reactions throughout the body. By depleting excess homocysteine, folate benefits cardiovascular health and nervous system function.

Those who take ordinary folate supplements, however, may not be experiencing its full spectrum of effects. This is because once ingested, not everyone converts folate to its biologically active form called  5-methyltetrahydrofolate (5-MTHF).Research shows that in a large proportion of the population, genetic enzyme deficiencies prevent the conversion of folate to 5-MTHF, leaving many vulnerable to low blood folate levels (and higher than desired homocysteine).

A more useful approach is to take the bioactive folate 5-MTHF directly, which has been declassified as a drug and is now available as a dietary supplement. 5-MTHF has been shown to dramatically raise red blood cell folate concentration, an indicator of folate status compared with folic acid supplementation. This bioactive folate is up to seven times more bioavailable than folic acid. This greater bioavailability is especially important in people who have a genetic enzyme deficiency since it requires no conversion to become metabolically active.

A study of 10 patients with endothelial dysfunction showed complete reversal of endothelial impairment after 5-MTHF supplementation compared with healthy control patients.

People with elevated homocysteine levels have a greater risk of cognitive decline. Unlike folic acid, 5-MTHF is able to cross the blood-brain barrier, which is especially important for people with cognitive difficulties to enhance the synthesis of acetylcholine in the brain — the neurotransmitter associated with memory.

Studies also show that the effectiveness of 5-MTHF can be further enhanced by co-supplementing with methylcobalamin (the active form of vitamin B12), vitamin B6, and riboflavin.

Suggested Use

Read the entire label and follow directions carefully prior to use.

Take one (1) capsule daily with food, or as recommended by a healthcare practitioner.

Other Ingredients

Microcrystalline cellulose, vegetable cellulose (capsule), silica, vegetable stearate.

This product contains no milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, corn, or rice. Contains no sugar, and no artificial sweeteners, flavors, colors, or preservatives.

  • Keep out of reach of children.
  • Do not exceed recommended dose.
  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Store tightly closed in a cool, dry place.

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Supplement Facts
Serving Size: 1 Vegetarian Capsule
  Amount per Serving % Daily Value
Folate [as (6S)-5-Methyltetrahydrofolic acid, glucosamine salt] 1000 mcg 250%

iHerb Customer Reviews

5 Stars
4 Stars
3 Stars
2 Stars
1 Stars

Helpful for fatigue

Posted by Reviewer2484240 on Dec 11, 2012

This plus magnesium orotate has helped immensely with my problems with fatigue. After my doctor said she had no more ideas as to how to help with fatigue she suggested I might have chronic fatigue syndrome. I did some research and found that the protocol of these two supplements were supposed to help. To my amazement, they've helped me. Because of the cost I tried to stop taking them but found that my fatigue returned, which convinced me these supplements work.

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10 people found the following review helpful

Very pleased

Posted by 4709873229285068209 on Nov 03, 2013

I have been taking this supplement for a few weeks and I am pleased with the results. My doctor said all my blood work looks good and my pregnancy is healthy so far! I have a genetic mutation that prohibits my body from processing folic acid properly, so it is very important that I take a bioavailable form of folate to supplement my diet to help decrease the risks of abnormalities developing during early pregnancy.

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6 people found the following review helpful

great product

Posted by 4780888759469417669 on Sep 03, 2013

I started using this form of Folate on the recommendation of a naturopath - and I will never go back to the other Folic Acid form! This one is by far the most effective form for me.

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4 people found the following review helpful


Posted by 4768746189220074113 on Jan 30, 2013

I found I had much more motivation/lifteed spirits.. I cut my anti-depressant in half, and use one of these every second day... Regards Ingrid/Australia

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3 people found the following review helpful


Posted by Reviewer2358485 on Nov 08, 2013

I gave this 2 stars because my doctor told me I need a MUCH higher dose than is recommended on this bottle. If I were to take as much as she (dr.) says I need, I would be absurdly expensive! There is a prescription you can get, and fill it with Pam Labs. It is compounded there so that you can take it in the l-methylfolate form, which is what enables it to cross the blood brain barrier. I take it as a mood stabilizer.

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3 people found the following review helpful

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