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Now Foods, SAM-e (S-Adenosyl-L-Methionine), 200 mg, 60 Tablets

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In Stock
  • Expiration Date: Jun 2018
  • Shipping Weight: 0.59 lbs (0.27 kg)
  • Product Code: NOW-00138
  • UPC Code: 733739001382
  • Package Quantity: 60 Tablets
  • Dimensions: 2 x 2 x 3.7 in, 0.35 lbs (0.16 kg)
Bundle Offer
Save $4.00 when you purchase these items today for only $36.26
Total: $40.26
Combo Discount: - $4.00
Together: $36.26

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Product Overview


  • Nervous System Support
  • Supports Cartilage Production
  • With B-Vitamin Cofactors
  • Enteric Coated
  • A Dietary Supplement
  • Vegetarian/Vegan
  • GMP Quality Assured

SAMe (S-adenosylmethionine), a compound native to the body, is a critical component of many biochemical reactions, including those that affect brain biochemistry and joint health. SAMe is critical for the synthesis of neurotransmitters, is important for energy production in the brain, contributes to the maintenance of healthy cell membrane function, and influences cartilage metabolism. NOW SAMe is enteric-coated, which makes it very well tolerated and protects it from degradation.

Suggested Use

As a dietary supplement, take 1 tablet 1 to 2 times daily, preferably on an empty stomach.

Refrigeration recommended after opening.

Other Ingredients

Cellulose, croscarmellose sodium, magnesium stearate (vegetable source), silica, stearic acid (vegetable source), ascorbic acid, citric acid and enteric coating (cellulose, triethyl citrate, methacrylic acid).

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.


Do not eat freshness packet. Keep in bottle.

Caution: For adults only. Individuals with bipolar (manic) depression and those with anxiety disorders should not take SAMe unless under professional medical supervision. Consult physician if pregnant/nursing, taking medication, or have a medical condition. Keep out of reach of children.

Supplement Facts
Serving Size: 1 Tablet
  Amount Per Serving % Daily Value
Vitamin B-6 (from Pyridoxine HCl) 2 mg 100%
Folic Acid 200 mcg 50%
Vitamin B-12 (as Cyanocobalamin) 50 mcg 833%
SAMe (S-Adenosyl-L-Methionine) (from 400 mg of S-Adenosyl-L-Methionine Disulfate Tosylate) 200 mg
† Daily Value not established.
iHerb Customer Reviews

Beware - this contains different ingredients to the 100mg

Posted by 5532317483647110197 on May 03, 2016

We had been using the 100mg SAM-e for a few months but were advised by our practitioner to increase the dose to 200mg. I bought the 200mg in what looked like the same product, but realized after my sons behavior deteriorated that it contains different ingredients, including Folic Acid, which does not agree with many. These products need more differentiation.

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great product for some, but maybe not for everyone

Posted by 4974559150175106973 on Sep 22, 2013

Mild and gentle, but still a definite lift in mood and energy on only one a day for me, but didn't work for daughter--made her more anxious.

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Posted by kanaca on Aug 05, 2013

Love all the sizes of SAMe, and just as good as Jarrow

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Good product

Posted by 5435030093168394235 on Aug 14, 2012

Help for depression and feeling energetic

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Perfect as in Fresh Vitamins Stores

Posted by Reviewer2551207 on Jun 30, 2011

Thank you for offering the same products as I used to buy for a whole lot more. As a senior on fixed incomes we really do not have much to spend and my Dr. has prescribed this for me to get better. Thank you again for your continued low priceing. John Chapman

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