Your Cart is Empty
But it doesn't have to be.
Continue Shopping.
Added to Cart
Cart Total:
Customers Also Bought:

Source Naturals, SAM-e (S-Adenosyl-L-Methionine), 400 mg, 30 Enteric Coated Tablets

Our Price:
You Save:
$20.69 (46)
Earn 10% Loyalty Credit ?

This product is already in your Wish List.

View Wish List

This product is now in your Wish List.

Sorry, this product is no longer in stock.

In Stock
  • Expiration Date: May 2018
  • Shipping Weight: 0.25 lbs (0.11 kg)
  • Product Code: SNS-01400
  • UPC Code: 021078014003
  • Package Quantity: 30 Enteric Coated Tablets
  • Dimensions: 1.5 x 3.3 x 5.1 in, 0.15 lbs (0.07 kg)
Product Overview


  • Supports Joint Comfort, Function and Mobility
  • Double Strength
  • Dietary Supplement
  • S-Adenosyl-L-Methionine

Source Naturals SAMe is a stable, bioavailable form of S-adenosyl-L-methionine. These tablets are enteric coated and blister packed to prevent breakdown and inactivation of the ingredients.

Dozens of clinical studies have demonstrated that SAMe supports joint comfort, function and mobility in the spine, hips and knees. It is important to the joints because of its critical role in cartilage formation. SAMe helps to form proteoglycans, which are used to renew the matrix of cartilage.

The studies also show that SAMe helps support a positive outlook. It is able to cross the blood-brain barrier, where it affects the synthesis and activation of various proteins, such as neurotransmitters. SAMe also plays a role in transmethylation. Transmethylation reactions affect the synthesis, activation, and metabolism of various biological molecules. Some compounds that SAMe methylates are phospholipids. This is a fundamental step in the mediation of cell to cell communication.

SAMe is present in every living cell in the body and plays an important part in many critical cellular functions. However, levels of SAMe tend to decline with age.

Suggested Use

1 tablet, 1 to 3 times daily. Take tablets on an empty stomach.

Other Ingredients

Cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, silica, stearic acid, glyceryl triacetate, sodium starch glycolate, modified cellulose gum, titanium dioxide and yellow ochre.

Suitable for vegetarians. Contains no yeast, dairy, egg, gluten, soy or wheat. Contains no sugar, salt, preservatives, or artificial flavor or fragrance.


If you are pregnant, may become pregnant, breastfeeding or are taking antidepressant medication, consult your physician before using this product. Use this product under medical supervision if you have bipolar disorder. In a small percentage of people this product may cause nausea or gastrointestinal upset. If you experience discomfort, discontinue use.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

Supplement Facts
Serving Size: 1 Tablet
Servings Per Container: 30
  Amount Per Servings % Daily Value
SAMe (s-adenosyl-L-methionine) from 800 mg of SAMe disulfate tosylate 400 mg
†Daily Value not established.
iHerb Customer Reviews

I am definitely happier after using this product for 2 weeks

Posted by 5375783669111175622 on Oct 18, 2016

I can vouch that it worked for me. Two and a half weeks later I am feeling more optimistic and steadier. Pre menopausal blues have started to lift. I am hesitant to recommend it as a natural anti depressant because I know it does not work for everyone. In saying that, it worked for me and I am grateful.

Verified Purchase

Was this review helpful to you?

Great Product

Posted by 5586896955355261579 on Jan 08, 2014

Great product, very effective. Been using for a month and will continue to use. Has improve my general well being. Mood, mobility and funny enough my skin complexion.

Verified Purchase

Was this review helpful to you?


Posted by 5219846649855951187 on Dec 27, 2013

Find it helps distress and relax, use it along with St Johns Wort, is just the extra boost needed to help cope with looking after both wife and father-in-law, who both have cancer.

Verified Purchase

Was this review helpful to you?

good value

Posted by 5419148741403620066 on Oct 18, 2013

good quality at a good price

Verified Purchase

Was this review helpful to you?

Extreme Nausea

Posted by Reviewer3272543 on Feb 14, 2013

Unfortunately, I experienced extreme nausea from this supplement and had to throw it out after trying it twice to be sure. Although I have a history of migraines and sensitivity to ingredients, nausea is a common side effect of SAMe. It's recommended to take on an empty stomach for best absorption and on a full stomach if nausea happens. I felt so ill I did not want to even try it on a full stomach. Wish there had been a trial size.

Verified Purchase

Was this review helpful to you?