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Source Naturals, SAM-e (S-Adenosyl-L-Methionine), 400 mg, 30 Enteric Coated Tablets

By Source Naturals

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$20.69 (46%)
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  • Product Code: SNS-01400
  • UPC Code: 021078014003
  • Package Quantity: 30 Enteric Coated Tablets
  • Dimensions: 1.5 x 3.3 x 5.1 in, 0.15 lbs (0.07 kg)

Product Overview

  • Supports Joint Comfort, Function and Mobility
  • Double Strength
  • Dietary Supplement
  • S-Adenosyl-L-Methionine

Source Naturals SAMe is a stable, bioavailable form of S-adenosyl-L-methionine. These tablets are enteric coated and blister packed to prevent breakdown and inactivation of the ingredients.

Dozens of clinical studies have demonstrated that SAMe supports joint comfort, function and mobility in the spine, hips and knees. It is important to the joints because of its critical role in cartilage formation. SAMe helps to form proteoglycans, which are used to renew the matrix of cartilage.

The studies also show that SAMe helps support a positive outlook. It is able to cross the blood-brain barrier, where it affects the synthesis and activation of various proteins, such as neurotransmitters. SAMe also plays a role in transmethylation. Transmethylation reactions affect the synthesis, activation, and metabolism of various biological molecules. Some compounds that SAMe methylates are phospholipids. This is a fundamental step in the mediation of cell to cell communication.

SAMe is present in every living cell in the body and plays an important part in many critical cellular functions. However, levels of SAMe tend to decline with age.

Suggested Use

1 tablet, 1 to 3 times daily. Take tablets on an empty stomach.

Other Ingredients

Cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, silica, stearic acid, glyceryl triacetate, sodium starch glycolate, modified cellulose gum, titanium dioxide and yellow ochre.

Suitable for vegetarians. Contains no yeast, dairy, egg, gluten, soy or wheat. Contains no sugar, salt, preservatives, or artificial flavor or fragrance.


If you are pregnant, may become pregnant, breastfeeding or are taking antidepressant medication, consult your physician before using this product. Use this product under medical supervision if you have bipolar disorder. In a small percentage of people this product may cause nausea or gastrointestinal upset. If you experience discomfort, discontinue use.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

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Supplement Facts
Serving Size: 1 Tablet
Servings Per Container: 30
  Amount Per Servings % Daily Value
SAMe (s-adenosyl-L-methionine) from 800 mg of SAMe disulfate tosylate 400 mg
†Daily Value not established.

iHerb Customer Reviews

5 Stars
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1 Stars

Good for a variety of health issues

Posted by Reviewer1925810 on Jun 01, 2008

Excellent product. In Europe, this supplement is a prescription product and is the #1 prescription for depression. In their clinical studies, they prescribe 1200 to 1600 mg daily (that is 3 to 4 of the double strength each day). I mention this to help others, because at this dosage it really, really helps beat some of my fibromyalgia and arthritis pain, gives some mental alertness and a better mood, and it also helps protect the liver when you have to take other prescription meds that might comprimise liver function. At iherb's price, it costs about $60 a month at the 3 daily dose, which is worth it for the difference it makes. I can always tell the decline in health when I let my supply run out. Best of Health to you!

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9 people found the following review helpful

Has phthalates and modified ingredients.

Posted by Reviewer2588518 on Nov 03, 2007

I noticed they have some questionable ingredients, namely, modified cellulose gum and hydropropyl mehylcellulose phthalate. I have heard very bad things about phthalates and have been trying to avoid them. I tried to contact the company and they gave me an email to which there has been no response.

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6 people found the following review helpful

Sam-e from Source natural

Posted by Reviewer3212554 on Aug 05, 2008

High potency product. Stareted feeling stomach ache with 400 mg/per day. Reduced to 200 mg. Good for aches, pain and liver.

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3 people found the following review helpful

Great product!

Posted by Reviewer1661186 on Jan 21, 2010

I've been using this product for a year and 1/2 now; it has produced wonderful results for my joint pain.

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3 people found the following review helpful

Sam-e at a good price

Posted by Reviewer1406404 on Jan 23, 2007

It's a good product, and the price is good, better than Sam-e at the health food store even when they have a two for one sale! The Natural Factors Sam-e is a good value, too, but I like the protective packaging on this brand.

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2 people found the following review helpful

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