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|Combo Discount:||- $4.00|
- Dietary Supplement
In order for vitamin B12 to be absorbed in the gastrointestinal tract, it first needs to be bound in the stomach to a protein called R-protein. In the intestines pancreatic proteases cause the R-protein to release vitamin B12 to bind with intrinsic factor, making it absorbable. Thorne Research's Bio-B12 contains methylcobalamin (an active form of vitamin B12) and 5-MTHF (an active form of folate) in a base of papain. Papain is a potent protein-digesting enzyme from papaya that also results in the release of vitamin B12 from the R-protein, thus facilitating the absorption process. Zinc picolinate is included for support of the pancreas, which produces other digestive enzymes that facilitate the absorption process.
Methylcobalamin (an active form of vitamin B12) is essential for recycling homocysteine and the formation of methyl donors involved in cardiovascular function, sleep, blood cell formation, and nerve function. Most vitamin B12 supplements contain cyanocobalamin; however, the liver must first "detoxify" the cyanide molecule and attach a methyl group to form methylcobalamin from the cyanocobalamin. Methylcobalamin is already in the biologically active, tissue-ready form. Evidence indicates the body utilizes methylcobalamin more efficiently than it does cyanocobalamin. Research shows the quantity of cobalamin detected following a small oral dose of methylcobalamin is similar to the amount following administration of cyanocobalamin; but significantly more cobalamin accumulates in liver tissue following administration of methylcobalamin. Human urinary excretion of methylcobalamin is about one-third that of a similar dose of cyanocobalamin, indicating substantially greater tissue retention.
Take 1 capsule one to three times daily or as recommended by your health-care practitioner.
Hypromellose (derived from cellulose) capsule, microcrystalline cellulose, silicon dioxide.
Tamper Evident: Use only if bottle is sealed. Store tightly sealed in a cool, dry place.
If pregnant, consult your health-care practitioner before using this product.
|Serving Size: One Capsule|
|Each Capsule Contains:||Amount Per Serving||% DV|
|Vitamin B12 (as methylcobalamin)||1 mg||16,667%|
|Folate (as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt)||800 mcg||200%|
|Zinc (as Zinc Picolinate)||15 mg||100%|
|*Daily Value (DV) not established.
†This product uses Gnosis S.p.A.'s L-5-Methyltetrahydrofolic Acid, Glucosamine Salt (Quatrefolic).
††An enzyme derived from Papaya (Carica papaya).
I'm trying to find a B12 that is compatible with my body. Thorne used to make B12 in the Adenosyl B12 form. Now all i can find are the Methyl (this product)B12, and the Cyano B12 forms of B12. The Cyano form makes cyanide in the body as it is metabolized. The Methyl form seems to be difficult for my body to metabolize.
It contains one of the two only really working B12 metabolites (methylcobaline) with a high dose of Folic acid. Is one of the most hypo allergenic products I know Hans Reijnen, docter for Homeopathy and Bio-Information Therapy, the Netherlands
Good formulation, gets smelly
Posted by 4774712930690073102 on Sep 14, 2016
Like many Vit.B supplements, these caps DO have a definitive smell to them that becomes stronger the longer they sit in the bottle. Unavoidable, really, but did get to the point where I wasn't taking them because of how strong they smelled!
Posted by 4677902882042607339 on May 07, 2015
I need to supplement both b12 and zinc, so this is a good combination: b12 as methylcobalamin and zinc in picolinate form. Plus, it is good to know there are no preservatives and fillers in Thorne Research products and they are free of all major allergens.
Very active formula
Posted by 4712849957199818320 on Sep 08, 2014
One of the most active formulas. Seen results from the first days I started them.
If you're taking metformin you should take B-12
Posted by Reviewer2650401 on Dec 11, 2011
It's for my mom. Her doctor advised that Her mess depletes vitamin B levels and to supplement. this is contain zinc which is also important.