Thorne Research, Indole-3-Carbinol, 60 Veggie Caps
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- Dietary Supplement
- To Support Estrogen Metabolism
- Maintains Optimal 2-Hydroxy/16-Hydroxy Estrogen Ratios
- Found in Cabbage Family Vegetables, it's a Source of DIM
- Nutritional Support for Liver Detoxification
- Made Without Flowing Agents that can Inhibit Bioavailability
Indole-3-carbinol (I3C) is a compound found in high concentrations in vegetables of the Brassica family, including broccoli, cauliflower, Brussels sprouts, and cabbage.
As a dietary supplement, I3C provides key nutritional support for liver detoxification. It also plays an important role in supporting female reproductive health. The majority of ingested I3C is absorbed in the small intestine as diindolylmethane (DIM), which is thought to be the primary contributor to I3C's beneficial properties. DIM has been shown to selectively bind to estrogen receptors and may act as an estrogen antagonist at physiological concentration.
In the liver, I3C promotes the metabolism of estrogen and increases the ratio of 2-hydroxy estrogen to 16-hydroxy estrogen. The 2-hydroxy estrogens, less active than the 16-hydroxy estrogens, generally are eliminated more rapidly from the body. One prospective study found postmenopausal women with the most favorable urinary 2:16-hydroxyestrone ratio were most likely to maintain good female health.
Preliminary studies have examined the efficacy, safety, and optimal supplementation of I3C. A 12-week phase I trial conducted on 17 women found a 66-percent increase in urinary 2:16-hydroxyestrone ratio with administration of 400 mg I3C daily.
Take 1 capsule one to two times daily or as recommended by your health-care practitioner.
Hypromellose (derived from cellulose) capsule, microcrystalline cellulose, leucine, silicon dioxide.
Tamper Evident: Use only if bottle is sealed.
If pregnant, consult your health-care practitioner before using this product.
Store tightly sealed in a cool, dry place.
|Serving Size: One Capsule|
|Amount Per Serving||% DV|
|Indole 3-carbinol / Diindolylmethane (DIM) complex||200 mg||*|
|* Daily Value (DV) not established.|
This is a good product for getting rid of extra estrogen in your body that may not have cleared out properly. It's good if you are estrogen-dominant and need some help to clear it out naturally. Doctor recommended. Safe.
Unfortunately, it may make the thyroid go slower.
Great product with no fillers
Posted by 5314027903119101750 on Mar 21, 2016
This is the purest I-3-C currently available on i-Herb and represents great value for money
Posted by Reviewer2800481 on May 29, 2014
Have just started taking for breast protection and hormone balancing
My doctor prescribed for high estrogen levels
Posted by pareedus on May 26, 2014
My doctor tested me and my estrogen was 4 times what it was supposed to be, with the side effects that come with that. I have been taking this for a couple of years, and have not been re-tested, but I do feel less angry and prone to fly off the handle. I don't know why other reviewer have said this product 'tastes bad' or 'smells funny'. It's a gelatin capsule- you don't chew it, you swallow it! It's fine to me, I haven't noticed those things and I am focused on the benefits.
Posted by adechamplain on Jan 02, 2014
Indole 3 Carbinol is a great compound found in surfuric foods like broccoli , cabbage, kale, and so on. Helps control oestrogen levels but can also inhibit the thyroid so worth checking with blood tests every now and then. I only started two weeks ago so might have to give this a longer try to see the effects.