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Doctor's Best, SAM-e (S-Adenosyl-L-Methionine) (S-Adenosyl-L-Methionine) 200, 60 Enteric Coated Tablets

By Doctor's Best

MSRP:
$39.99
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$19.68
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$20.31 (51%)
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In Stock
  • Product Code: DRB-00206
  • UPC Code: 753950002067
  • Package Quantity: 60 Enteric Coated Tablets
  • Dimensions: 6.3 x 3.3 x 1.7 in, 0.15 lbs (0.07 kg)

Product Overview

Description
  • Science-Based Nutrition
  • Pharmaceutical Grade
  • Dietary Supplement With 200 mg Active S-Adenosyl Methionine Per Tablet
  • Enhances Mood & Neural Function
  • Promotes Joint Comfort & Mobility
  • Supports Liver Health & Detoxification
  • Vegan
  • Sealed in Blister Packs for Freshness & Convenience

S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.

Supplementing with SAMe

The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in our SAMe 200 is processed to yield the highest available percentage of the active pure S,S form on the market.

SAMe and Joint Function

SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.

SAMe and Neural Health

SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.

SAMe and Liver Function

SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.

Our SAMe 200 contains 200 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.

Suggested Use

Adult Use: Take 1 tablet daily away from food, or as directed by a health care professional. Do not chew or crush tablet.

Other Ingredients

Cellulose gel, methacrylic acid copolymer, compritol 888ATO, talc, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silica, medium chain triglycerides, sodium starch glycolate and iron oxide.

The SAMe found in Doctor's Best SAMe 200 mg is free from yeast, dairy, gluten, soy, wheat, and artificial flavoring.

Contains nothing other than listed ingredients.

Warnings

Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.

SAMe 200 is sealed in blister packs for freshness and stability.

Store product in a cool, dry place to ensure maximum quality.

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Supplement Facts
Serving Size: 1 tablet
Servings Per Container: 60 servings
  Amount per serving % Daily Value
S-Adenosyl Methionine (from 400 mg of SAM-e tosylate disulfate) 200 mg
† Daily Value not established.

iHerb Customer Reviews

5 Stars
4 Stars
3 Stars
2 Stars
(2)
1 Stars
(8)
 

Sam-e made me spacey

Posted by Reviewer3033976 on Jul 29, 2010

Ordered this product for moodiness and slight depression. I thought it would take some time for it to work, but right after I took the first one, instead of getting ready for my date with my friend, I went upstairs and lied down and stared at the ceiling for at least 30 minutes. I remained at taking one capsule a day and continued to feel dopey and spaced out. At work I tripped at least two times and couldn't focus on what I was doing. On the weekend I had to take a nap in the afternoon and didn't wake up until 9pm. I think I would consider taking this again for my first day of my periods or for severe pms, but I can't take this and work. It feels like I'm on a recreational drug or something. It works right away so keep that in mind; and also it did improve my mood. Found myself having the urge to sing and dance for no specific reason.

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12 people found the following review helpful

Better than prozac

Posted by Reviewer2494531 on Jan 03, 2011

One of the most important parts of the methylation cycle for helping depression. Must have ! Noticed differnace in 10 days.

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10 people found the following review helpful

Good, but higher doses work better

Posted by Reviewer1342755 on Sep 14, 2009

This is the best Sam-e Ive tried, but it is definitely more effective in a higher dose. I am a Fibromyalgia/Chronic Fatigue sufferer, and this definitely helps with my associated depression.

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9 people found the following review helpful

Feeling better

Posted by Reviewer3057108 on Dec 25, 2009

I decided to try Sam-e after because I wanted to wean off my Paxil. I can honestly say my mood has been stabil. My husband has been using it as well, and he has been sleeping much better. (We take it in the morning) A little stomach upset for me, so I will start using it with food. I think this is a good quality product.

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7 people found the following review helpful

Wonderful

Posted by Reviewer3291104 on May 01, 2010

We bought both the 200mg and 400mg dose. We bought both because I worry a lot and that increased with the onset of perimenopause. The SAM-e has helped my whole family. That tightness from worrying is gone - as well as the worrying. When I feel the anxious, I take a 400mg pill. I read in Mind Boosters by Ray Sahelian M.D. that he took 800mg dose throughout the day without side effects. I haven't taken more than 600mg in one day and have not experienced any side effects. SAM-e takes the edge off - like a glass of wine only without the calories and it lasts a lot longer.

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7 people found the following review helpful

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