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Doctor's Best, SAM-e (S-Adenosyl-L-Methionine) 200, 60 Enteric Coated Tablets

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In Stock
  • Expiration Date: Nov 2018
  • Shipping Weight: 0.35 lbs (0.16 kg)
  • Product Code: DRB-00206
  • UPC Code: 753950002067
  • Package Quantity: 60 Enteric Coated Tablets
  • Dimensions: 6.3 x 3.3 x 1.7 in, 0.15 lbs (0.07 kg)
Product Overview


  • Science-Based Nutrition
  • Pharmaceutical Grade
  • Dietary Supplement With 200 mg Active S-Adenosyl Methionine Per Tablet
  • Enhances Mood & Neural Function
  • Promotes Joint Comfort & Mobility
  • Supports Liver Health & Detoxification
  • Vegan
  • Sealed in Blister Packs for Freshness & Convenience

S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.

Supplementing with SAMe

The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in our SAMe 200 is processed to yield the highest available percentage of the active pure S,S form on the market.

SAMe and Joint Function

SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.

SAMe and Neural Health

SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.

SAMe and Liver Function

SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.

Our SAMe 200 contains 200 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.

Suggested Use

Adult use: Take 1 tablet daily away from food, or as recommended by a nutritionally-informed physician. Do not chew or crush tablet.

Other Ingredients

Cellulose, methacrylic acid copolymer, glyceryl behenate, magnesium silicate, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silicon dioxide, medium chain triglycerides, sodium carboxymethyl starch and iron oxide.

The SAMe found in Doctor's Best SAMe 200 mg is free from yeast, dairy, gluten, soy, wheat, and artificial flavoring.

Contains nothing other than listed ingredients.


Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.

SAMe 200 is sealed in blister packs for freshness and stability.

Store product in a cool, dry place to ensure maximum quality.

Supplement Facts
Serving Size: 1 tablet
Servings Per Container: 60 servings
  Amount per serving % Daily Value
S-Adenosyl Methionine (from 400 mg of SAM-e tosylate disulfate) 200 mg
† Daily Value not established.
iHerb Customer Reviews

For joints

Posted by 5234728829999803621 on Oct 08, 2016

I keep ordering this product. Has been helpful for arthritis taking it two-three tablets per day together with Wobenzym.

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Just bought 2nd packet

Posted by 5415105463578657671 on Oct 04, 2016

I'm really pleased with this product. Started using to manage low mood and have had good results, I've just reordered my 2nd pkt.

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Good product

Posted by 5746541782230867343 on Sep 25, 2016

Regulate my body's need. I suffer from adrenal burnout. When i get tired i feel anxiety. Sam-e help me with this fantastic. It gives me energy. It can make me feel panic anxiety and terribly tired when i take it when i get cold and influenza. It means maybe i have to relax and sleep instaed of being awaken and press my self. I take one morning and one when i feel exausted and anxiety during day . Two is enough for me. If u suffer from adrenal burnout i definitly recomand.

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Posted by 5652048142629969857 on Aug 23, 2016

My holistic doctor put me onto this 2 years ago and it absolutely saved me. I had about 30 of the symptoms for perimenopause and with in a few days I "levelled" out , excellent product

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Best SAMe

Posted by 5442167645098720552 on Jul 06, 2016

Because of the coating it works much better than SAMe without coating. Off course more expensive, but at it gets better absorbed. It keeps me pain free.

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