I have osteoarthritis in my knees probably due to heavy weight training, lifting heavy patients at work & a meniscus tear in my rt knee 2 yrs ago. I have minor/ moderate pain in my rt knee about 66% of the time. I have to take ibuprofen approx once per day most days because of nagging pain. After approx 1 week of taking this product, I noticed that I wasn't having to take ibuprofen to get through the day. I have tried any/all commbinations of glucosamine,chondroitin, cissus quadrangularis, fish oil, etc. separate & together. I feel that I've gotten more relief from Aid 4 Joints than any other product I've tried. Taking this with Celadrin makes it even more effective. I highly recommend this product.