I'm 46 and have rheumatoid arthritis. I had to quit taking Natrol's Tonalin CLA after just a few days. Basically... this stuff cranked my arthritic inflammation up to a point that I'd not seen in a long time. And the anti-inflammatory prescribed by my rheumatologist couldn't keep up despite increasing the frequency that I was taking it from once a week to nearly daily. I knew CLA was an omega 6. And that omega 6 fatty acids contribute to inflammation, especially if taken in too high a proportion as compared to omega 3 fatty acids. I figured I'd be fine though since I eat sardines about every other day and supplement omega 3s even further with daily Schiff Mega Red. I was way wrong! From my experience, this stuff kicks arthritis into high gear. I had no idea that omega 6s could have such a fast and harsh impact on inflammation.