Very pleased. Definite improvement in mood,outlook and sleep patterns. Have quite a bit of longterm experience with SSRI and SNRI antidepressants and other alternative therapies-st. johns wort,5 htp,fish oil,etc... I take 4 of these( L Try) at bedtime with the co-enzyme p 5 p version of b-6 50 mg (w/orange juice). NOW Foods makes the one I use. I also take low dose 5 mg Lexapro and I know for myself the L-Tryp definetly has a beneficial,additive effect w/out so many of the typical side effects associated with SSRI therapy. Also take magnesium,Vit C, B complex,multi vitamin... Grateful and very pleased.

Definetly has pos. effect on mood,outlook and quality of sleep. Appears to diminish appetite too. Does effect dreams. Need to be careful with the dosage as I have experienced some GI upset/effects;but was taking a high dosage(300mg) BID.Will cut back and add Tyrosine back to regime to balance neurotransmitter synthesis.

Definetly helps. Improved my sense of smell too(histamine process is involved in the depression dynamic). Skin looked flushed though.

A very good,high quality multi at a great price. Well tolerated.

A highly effective form of magnesium that I tolerate very well. Great price. excellent results with all Now Foods products(no affiliation,commercial interest,etc...).

I have had very beneficial,therapeutic benefits since using this product . My normal dosage is 2 BID. I also take 150 mg of Effexor XR.Have noticed a significant improvement since adding the orotate. Bumped up the XR dosage and side effect profile worsened appreciably. Also,take Magnesium Glycinate,Vit C and a very good mens mult-vitamin. Drink plenty of water. I was a Drug Rep for many yrs. so I do have sign. clinical insight,background. All I can say is that for me this product has improved my moods,depression and outlook significantly. God bless and good luck.