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- Nervous System Support
- Supports Emotional Well-Being
- Supports Joint Health
- Enteric Coated
- A Dietary Supplement
- GMP Quality Assured
SAMe (S-adenosylmethionine), a compound native to the body, is a critical component of many biochemical reactions, including those that affect brain biochemistry and joint health. Numerous studies have indicated that SAMe can help to temporarily alleviate minor joint discomfort resulting from overexertion or stress. In addition, because SAMe is also necessary for the synthesis of neurotransmitters, it plays an important role in mood support. NOW SAMe is enteric-coated, which makes it very well tolerated and protects it from degradation.
As a dietary supplement, take 1 tablet 2 to 4 times daily, preferably on an empty stomach.
Refrigeration recommended after opening.
Cellulose, croscarmellose sodium, magnesium stearate (vegetable source), silica, stearic acid (vegetable source), ascorbic acid, citric acid and enteric coating (cellulose, triethyl citrate, methacrylic acid.)
Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Do not eat freshness packet. Keep in bottle.
Caution: For adults only. Individuals with bipolar (manic) depression and those with anxiety disorders should not take SAMe unless under professional medical supervision. Consult physician if pregnant/nursing, taking medication, or have a medical condition. Keep out of reach of children.
|Serving Size: 1 Tablet|
|Amount Per Serving||% Daily Value|
|SAMe (S-Adenosyl-L-Methionine) (from 800 mg of S-Adenosyl-L-Methionine Disulfate Tosylate)||400 mg||*|
|* Daily Value not established.|
I read about SAMe from a variety of sources. My psychiatrist gave it an o.k. for mood stabilization support, but warned that it costs a lot of money. Because of joint pain AND mood issues, I was hoping for a multi-treatment of sorts, which would enable me to reduce or eliminate a few other meds. I ordered what I predicted was a 6 week supply, based on the dosing my MD suggested. I am pressing on, determined to finish the first 60 tablets, and regretting the purchase. Although "side effects may go away over time", I've about had enough. At 400, mgs, I had severe abdominal pain the first few days, diminshing to a mere loss of appetite beyond. Increasing the dose by 400 mgs/week (with permission to increase all the way up to 2400 from MD)I am now up to 1200 mgs. I will abandon this experiment at the end of the week, unless I find my knee pain improved, and the stomach pain/loss of appetite thing gone. As for mood, no one in pain and without good diet, due to loss of appetite, can be real happy. As for the money, not worth it for me. AND, come to find out from the Naturopath, SAMe is very unstable, must be refridgerated at ALL times, no matter what the product label says, should be purchased only in a blister pack etc. I have three unopened bottles left. I will ask whether iHerb will take them back, but I doubt they will. My mistake. I should have researched this one more carefully.
This is a life saver. It really does ease joint pain, lift depression, and I can't tell about it cleansing the liver part. It's not that we are not on speaking terms, I just don't know what my liver feels like. But I do know that my hubby and I both take it every morning. We communicate better and stay more focused and have much less depression. Again a healthy life style helps and this gives us a good start toward it.
Posted by 4807734581378084172 on Nov 30, 2016
I won't live without this brand of SAM-e. Great for mood enhancement and reduction of joint pain.
undermethylation - under control
Posted by 4829150388368381040 on Mar 10, 2016
See what I did there? ;) I have been advised to take one tablet per day for undermethylation and within the first month I felt notable signs of improvement. I am taking this as part of a high dose vitamin regime but SAMe is the first to take effect. Makes me drowsy so I take at nighttime with no other adverse side effects. Very satisfied.
No good compared to other brands
Posted by Reviewer2142008 on May 12, 2015
I'm very chemically sensitive when ever I have herbs oor supplements I notice an effect right away. I'll know within 1/2 hrs if something works. I have extreme anxiety and depression, started using a different brand and wow, what a difference. Changed over to NOW SAM-e and within two days I'm back to feeling shocking and crying I was so confused, tried the other brand as I hadn't finished it due to tummy troubles and boom my great mood came back. This brand does not work 100%, it has very mild effect that obviously other ppl feel but my god don't waste your money on a formula that is weak. I have two bottles of this stupid stuff and I don't know what to do with it, take it and be miserable or throw $120 down the drain. I wanted to let everyone know because there is way to many wrong positive comments on here!!!!!!!
Using SAMe since 2008
Posted by Reviewer1743995 on Apr 01, 2015
I've been using SAMe since 2008 for mood (since I was 28 yrs old), and now subsequently for joint health. One 400mg daily is the dose that I take, mid-morning. I have absolutely no side effects that I can identify, and it does not affect my stomach at all, and I have a sensitive stomach. On the flip side, I was suggested to try TMG, which is the precursor to SAMe and much much cheaper, BUT, that gives me super crazy migraines, so sorry TMG, you don't take the place of my SAMe. And I have to say, iHerb price for 60 x 400mg caps is the best I have found anywhere. Even though I have to pay over $40.00 in shipping to Canada, its still half the price per container, if I were to order locally (30 x 400mg costs $51.00 CAD elsewhere, versus 60 x 400mg $50.47 USD). So the more I order, the more I save via iHerb.