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Doctor's Best, SAM-e (S-Adenosyl-L-Methionine) 400, Double-Strength, 30 Enteric Coated Tablets

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In Stock
  • Expiration Date: Feb 2019
  • Shipping Weight:
    0.37 lbs
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  • Product Code: DRB-00151
  • UPC Code: 753950001510
  • Package Quantity: 30 Enteric Coated Tablets
  • Dimensions:
    1.8 x 3.3 x 6.3 in, 0.15 lbs
    Switch to Metric units
Product Overview


  • Science-Based Nutrition
  • Dietary Supplement with 400 mg Active S-Adenosyl Methionine Per Tablet
  • Enhances Mood & Neural Function
  • Promotes Joint Comfort & Mobility
  • Supports Liver Health & Detoxification
  • Pharmaceutical Grade
  • Sealed in Blister Packs for Freshness & Convenience
  • Suitable for Vegetarians

S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.

Supplementing with SAMe

The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market.

SAMe and Joint Function

SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.

SAMe and Neural Health

SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.

SAMe and Liver Function

SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.

Our Double-Strength SAMe 400 contains 400 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.

Double-Strength SAMe is sealed in blister packs for freshness and stability.

Suggested Use

Adult Use: Take 1 tablet daily away from food, or as recommended by a nutritionally-informed physician. Do not chew or crush tablet.

Other Ingredients

Cellulose, methacrylic acid copolymer, glyceryl behenate, magnesium silicate, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silicon dioxide, medium chain triglycerides, sodium carboxymethyl starch and iron oxide.

The SAMe found in Doctor's Best SAMe 400 mg (Double Strength) is free from yeast, dairy, gluten, soy, wheat and artificial flavoring.

Contains nothing other than listed ingredients


Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.

Store product in a cool, dry place to ensure maximum quality.

Supplement Facts
Serving Size: 1 tablet
Servings Per Container: 30 servings
  Amount per serving % Daily Value
S-Adenosyl Methionine (from 800 mg of SAMe tosylate disulfate) 400 mg
† Daily Value not established.
iHerb Customer Reviews

Works for men

Posted by elise87 on Feb 12, 2017

This product works for my husband. It doesnt really do anything for me.

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Doctor's Best SAME 400 Double Strength

Posted by 4973811074109829629 on Feb 07, 2017

I live in South Africa and after the supplier I usually use ran out of SAMe I ordered thru iherb. The quality of the product I got from SAMe is excellent - I felt better after a few days - and was delivered promptly but best of all, it is more than half the price cheaper than the one I used to buy! I can't believe I was so ripped off - I am never going back to the old supplier again. I guess the reason I didn't think of ordering online before was because I was a bit sceptical but iherb was truly excellent - I have ordered 3 times now and each time I got the same great service. Plus - when I sent a customer query, they responded promptly and I got to speak to a real person, not an anonymous customer service reply.

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Good product

Posted by 5530564982578978936 on Jan 19, 2017

Has made a difference for me, although have to admit that it is very pricey

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Posted by Reviewer1986419 on Jan 05, 2017

Hi, I have only just received this product a couple of days ago, so I can't really comment yet, but if it is as good as they say, health wise it is going to make a big difference to me. I will do another review over time if I notice any change in my health? Regards, Colleen Faed, Mandurah, Western Australia.

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Mood Changer

Posted by 4901901375085070023 on Dec 18, 2016

This product seems to make your mood very grumpy. I have not felt like this, very annoyed and aggrevated but as soon as stop taking it my mood changes back to more relaxed and able to feel like going with the flow . I have changed to taking it just before bed and this is better.

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