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Doctor's Best, SAM-e (S-Adenosyl-L-Methionine) 400, Double-Strength, 60 Enteric Coated Tablets

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In Stock
  • Expiration Date: Aug 2019
  • Shipping Weight:
    0.41 lbs
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  • Product Code: DRB-00252
  • UPC Code: 753950002524
  • Package Quantity: 60 Enteric Coated Tablets
  • Dimensions:
    6.3 x 3.3 x 2 in, 0.25 lbs
    Switch to Metric units
Product Overview


  • Science-Based Nutrition
  • Dietary Supplement with 400 mg Active S-Adenosyl Methionine Per Tablet
  • Enhances Mood & Neural Function
  • Promotes Joint Comfort & Mobility
  • Supports Liver Health & Detoxification
  • Pharmaceutical Grade
  • Sealed in Blister Packs for Freshness & Convenience
  • Suitable for Vegetarians

S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.

Supplementing with SAMe

The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market.

SAMe and Joint Function

SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.

SAMe and Neural Health

SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.

SAMe and Liver Function

SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver production. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.

Our Double-Strength SAMe 400 contains 400 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.

Double Strength SAMe is sealed in blister packs for freshness and stability.

Suggested Use

Adult Use: Take 1 tablet daily away from food, or as recommended by a nutritionally-informed physician. Do not chew or crush tablet.

Other Ingredients

Cellulose, methacrylic acid copolymer, glyceryl behenate, magnesium silicate, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silicon dioxide, medium chain triglycerides, sodium carboxymethyl starch and iron oxide.

The SAMe found in Doctor's Best SAMe 400 mg (Double Strength) is free from yeast, dairy, gluten, soy, wheat and artificial flavoring

Contains nothing other than listed ingredients.


Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.

Store product in a cool, dry place to ensure maximum quality.

Supplement Facts
Serving Size: 1 tablet
Servings Per Container: 60 servings
  Amount per serving % Daily Value
S-Adenosyl Methionine (from 800 mg SAM-e tosylate disulfate) 400 mg
† Daily Value not established.
iHerb Customer Reviews

Great product

Posted by 4622453091439142663 on Feb 12, 2017

I have been using this product for some time now and I love it

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Helps me to feel much better and I get better blood test results

Posted by 5539113384560379125 on Feb 03, 2017

I have a liver condition and this has been indispensable for me.

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It works for me

Posted by 4773436480667650802 on Jan 25, 2017

I have been taking it for 2 months now following suggestion from my nutritional GP and I am finding that it does help me. More energy and not feeling as flat as I was. I now have the energy to incorporate more exercise yet was too fatigued before. I will continue to buy it from this site as the price is good and no delivery issues. I started with 1x200 dose for a few days then took 2x 200 until I ran out and then changed to 1x400. I had tried St John's Wort before trying this product (on GP advice) however I had a photo sensitivity reaction to that so stopped that after only 5 days.

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Life saver

Posted by 5528039008663482135 on Jan 23, 2017

Great product for great price

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Very happy

Posted by 5452194734195078703 on Jan 19, 2017

I really didn't expect this to work but it does, at least for me. I noticed an improvement from the first day I started taking it. I looked into reasons why it would work so well for me and ended up having a DNA test to confirm what I was starting to suspect from what I have read. I learnt I have a methylation defect and SAMe helps correct the deficiencies this causes. For me it's been amazing.

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