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Thorne Research, Methyl-Guard Plus, 90 Veggie Caps

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In Stock
  • Expiration Date: May 2018
  • Shipping Weight:
    0.3 lbs
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  • Product Code: THR-78901
  • UPC Code: 693749789017
  • Package Quantity: 90 Veggie Caps
  • Dimensions:
    4.4 x 2.4 x 2.4 in, 0.25 lbs
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Product Overview


  • Dietary Supplement
  • Hypoallergenic
  • More Concentrated Methylation Support
  • Contains Higher Amounts of 5MTHF (Active Folate), B6, B12
  • Riboflavin 5'-Phosphate Added for Extra Homocysteine Metabolism Support
  • Easy 3 Capsules Daily Dosing

Methylation – the addition of a methyl group (CH4 – one carbon attached to three hydrogens) to another molecule – is an essential and vital biochemical process within the human body that is involved in a large number of biochemical pathways involving neurotransmitters, detoxification, cardiovascular health, eye health, muscle health, bone health, and redox balance. A number of specific nutrients are necessary for methylation to occur normally.

Methyl-Guard Plus contains higher amounts of 5MTHF (the active form of folate), pyridoxal 5'-phosphate (active B6), and methylcobalamin (active B12), than our original Methyl-Guard. We have also added riboflavin 5'-phosphate (the active form of vitamin B2) for its positive effect on homocysteine metabolism and methylation. These ingredients provide the necessary nutrients the body uses to push forward the process of methylation. Methyl-Guard Plus is more concentrated, so your patients will appreciate the recommended daily amount of three capsules, which will improve compliance. Our original Methyl-Guard is still available.

Suggested Use

Take 1-3 capsules daily or as recommended by a health-care practitioner.

Other Ingredients

Hypromellose (derived from cellulose) capsule, calcium citrate, calcium laurate.


Tamper evident: Use only if bottle is sealed.

If pregnant, consult your health-care practitioner before using this product.

Store tightly sealed in a cool, dry place.

Supplement Facts
Serving Size: Three Capsules
Servings Per Container: 30
Three Capsules Contain: Amount Per Serving %Daily Value
Riboflavin (as Riboflavin 5'-Phosphate Sodium) 90 mg 5,295%
Vitamin B6 (as Pyridoxal 5'-Phosphate) 45 mg 2,250%
Folate (as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 3 mg 750%
Vitamin B12 (as Methylcobalamin) 3 mg 50,000%
Betaine Anhydrous (Trimethylglycine) 1.8 g *
*Daily Value (DV) not established.
iHerb Customer Reviews

MTHFR mutation... no worries

Posted by 5151753229139787995 on Jan 28, 2017

If you have a serious methylation issue this should be your go to product for fixing it. Diet alone won't cut it. The recommended dose is three caps but I find that's too much if taken daily. I take one in the morning and one at night. Keeps my moods stable and energy levels stable. Basically if you have a MTHFR gene mutation issue and you want to return to a nice "average" then take this stuff.

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Methyl-Guard just right

Posted by 5241367841075007954 on Sep 22, 2016

Methyl-Guard is the only product we've found which helps with my daughter's mineral levels. So easy to order online and sent on time.

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Posted by 5326943429062627849 on May 08, 2016

Presribed by GP

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Posted by 5472773624811810040 on Apr 07, 2016

esp if you have an activated MTHFr gene mutation

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Methylguard Plus

Posted by Reviewer1065582 on Apr 04, 2016

Excellent supplement for people with Methylation Pathway issues. I take two every day.

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