- You earn loyalty credit for every order you place at iHerb!
- Loyalty credit is equal to 10% of the value of your order, excluding shipping charges.
- Your loyalty credits are valid for up to 60 days from the date of your last purchase.
This product is already in your Wish List.
View Wish List
This product is now in your Wish List.
- Supports Joint Comfort, Function and Mobility
- Enteric Coated Tablets
- Dietary Supplement
Source Naturals SAMe is a stable, bioavailable form of S-adenosyl-L-methionine. These tablets are enteric coated and blister packed to prevent breakdown and inactivation of the ingredients.
Dozens of clinical studies have demonstrated that SAMe supports joint comfort, function and mobility in the spine, hips and knees. It is important to the joints because of its critical role in cartilage formation.
SAMe helps to form proteoglycans, which are used to renew the matrix of cartilage.
The studies also show that SAMe helps support a positive outlook. It is able to cross the blood-brain barrier, where it affects the synthesis and activation of various proteins, such as neurotransmitters.
SAMe also plays a role in transmethylation. Transmethylation reactions affect the synthesis, activation, and metabolism of various biological molecules.
Some compounds that SAMe methylates are phospholipids. This is a fundamental step in the mediation of cell to cell communication.
SAMe is present in every living cell in the body and plays an important part in many critical cellular functions. However, levels of SAMe tend to decline with age.
2 tablets , 1 to 3 times daily. Take tablets on an empty stomach.
Cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, sodium starch glycolate, glyceryl triacetate, modified cellulose gum, stearic acid, colloidal silicon dioxide, titanium dioxide and yellow ochre.
Suitable for vegetarians. Contains no yeast, dairy, egg, gluten, soy or wheat. Contains no preservatives or artificial color, flavor or fragrance.
If you are pregnant, may become pregnant, breastfeeding or are taking antidepressant medication, consult your physician before using this product. Take this product under medical supervision if you have bipolar disorder. In a small percentage of people this product may cause nausea or gastrointestinal upset. If you experience discomfort, discontinue use.
Do not use if either tamper-evident seal is broken or missing. Keep out of the reach of children.
|Serving Size: 2 Tablets|
|Servings Per Container: 30|
|Amount Per Serving||%DV|
|SAMe (S-adenosyl-L-methionine) from 800 mg of SAMe disulfate tosylate||400 mg||†|
|† Daily Value not established.|
Would've rated it higher because in the pain-cessation category it works really well. However, I get stabbing digestive pains from it and nausea. I am trying a reduced dose and so far, not more than a twinge once in a while. Love the packaging.
i having just recently tryed sam-e and the effects were brillant for me,my anxiety and mild depression have dissapeared,i am in exellent form,i would highly recommend this product.ken [dublin ireland]
Not For My Sensitive System
Posted by Reviewer2814708 on Mar 23, 2014
I purchased this product with the hope that it would help relieve ongoing arthritis pain in my joints. As an added benefit, I also hoped it would even out my mood, which tends toward depression. While I do use other vitamin/mineral supplements by Source Naturals and believe this product to be of the highest quality, I had several adverse reactions on the very small dose of just 200mg a day. I took the product for nearly 3 weeks, but after the second week I began experiencing gastrointestinal irritation (rumbling, churning stomach) along with nausea, sweating, anxiety and a racing heart rate. As I always research supplements thoroughly before taking a new one, I was aware that these were possible side affects - some which could indicate other, more serious problems, such as Serotonin Syndrome. I have since discontinued using the product as it seems even the lowest dose is too strong for my body and all the symptoms have since subsided. So I would certainly caution anyone trying this product for the first time, to read up on it and make an informed decision. I do have to say that in the first couple weeks, when all was going well, I did notice at first, experiencing a calmer mood. I did not however notice any change in my arthritis pain.
I think it works
Posted by Reviewer2137328 on Sep 05, 2013
I can tell more when I DON'T take my SAMe than when I do. It certainly keeps me more productive when I may otherwise not feel like doing a dang thing. If you need that extra boost, I recommend this product. I've tried a few brands & prefer this one.
made me irritable and angry
Posted by Reviewer3085712 on Aug 09, 2013
Wow! Did not expect to have side effects with this product! My brother recommended that I try this for my arthritis. After a couple days, I started feeling very irritable and angry. Even my dogs noticed the change in my behavior. I quit taking it and went back to normal by the next day. I must be really sensitive to the CNS effects of SAMe. SSRI antidepressants had the same effect on me, also. Just be aware of the potential for unexpected effects.
Excellent so far
Posted by Reviewer1523405 on Oct 21, 2011
My son has A.S. so these have been found to elevate mood naturally. I am using in conjunction with B12 and N.A.C. So far there has been an uplifting of mood, and less stress. Love they are all naturally as will never use synthetic drugs on my kid.I have introduced gently as these can have adverse effects if too much.
Posted by Reviewer2471485 on Oct 04, 2011
I started taking this for relief for my fibromyalgia pain and I've been used for about 3 months now. Once in the morning before I eat anything and I can feel the effects nearly all day. If I'm having a bad day I'll double the dose.