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I take 2 per night, and it's fine if taken during the day as well. - It works as an adaptogen and general upregulating anti-oxidant (upregulating our own antioxidant systems) - It's a GABA-mimetic, so it should induce relaxation to some degree. - The Withanolide content is HIGH = induces neuronal growth and synaptic regeneration - It's a mild acetylcholinesterase inhibitor = more choline - Seems to increase T4-to-T3 thyroid hormone conversion Once one gets the dose and timing dialed in, and adjusts to the sedation (present in some people), it seems like a good choice.
Well designed formula
The inclusion of B6 as p5p was a good choice in conjunction with tryptophan. The Dr. Best formula includes B3 as niacinamide (which is a known soporific agent), but having added my own niacinamide, I cannot perceive any difference. Melatonin is synthesized AFTER serotonin. The synthesis of serotonin (and other neurotransmitters) is catalyzed by a B6-dependent enzyme. Furthermore, B6 is required to manufacture Niacin from tryptophan. Thus a reason one might choose tryptophan over melatonin is NOT to skip any intermediary steps (there are a few studies showing that direct melatonin supplementation reduces levels of intermediary products). I use low-dose melatonin anyway (Same brand, sustained release) because sleep is scarce.
I use it for sleep
This product helps me sleep. Bacopa, gotu kola, and a few of the other included ingredients in this formula have been studied with regard to cognitive performance: the results are generally mildly to moderately favorable, but often inconclusive. I've been told that Bacopa requires about 12 weeks to take effect - I've been taking this formula for longer than that, and while I believe it has helped me, I'm not sure that my mental performance has improved.
Good form of zinc
This brought my zinc levels back up, and it's a good source of orotic acid. I'm sure zinc aspartate would have done the same, but I take this at night in conjunction with magnesium glycinate (both NMDA inhibitors). I'd rather not have an excitatory neurotransmitter (L-aspartate) in circulation when I'm trying to sleep. For the supplementing athletes: D-aspartate lingers even longer.
Mild enough to use regularly
Posted by Reviewer1331472 on Jun 07, 2011 | Verified Purchase
It's an effective glycolic acid soap, but mild enough for frequent use. This is good for normal skin, but especially for mild to moderate acne and blemishes; it will brighten and somewhat clear the complexion after each use. Apply dry (face perhaps some to the neck / other problem areas), wait a few minutes, and then rinse. You may want to follow with a suitable moisturizer. Derma-E probably makes a good one; I'll give them a try when I run out of current stock.
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