Does have a noticeable effect on fine wrinkles, whether you take it internally for weeks or apply it topically for days. The effect disappears quickly once you stop, and I don't entirely trust the safety of this compound beyond what I get from eating generous helpings of wild salmon. Still I believe you get what's advertised here; I'm only holding out for more research.
Seems to get the job done! I take 4000 IU a day and this has eradicated the winter slump I've experienced every year as long as I can remember. Two years now without it. If you supplement vitamin D, make sure you also supplement vitamin K2. (I suggest Jarrow's MK-7.)
This appears to be going off the market. Excellent stuff--I'm building a stockpile while I can. The migraine benefit may come from the tendency of vitamin B-6 to increase the ratio of GABA to glutamate (the ratio runs low in migraineurs and epileptics). Do not combine more than 50 mg a day with nortriptyline, or your head will start going fuzzy and you'll make lots of arithmetic errors. There is a listed interaction, but I know not everyone checks.
Posted by iHerb Customer on Jul 25, 2009 | Verified Purchase
I took one every other day to counteract the CoQ10 depletion caused by nortriptyline. While it could be my imagination or something else, the nortriptyline seemed to become more effective at controlling migraines.
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