Curcumin protects the liver against ethanol, may heal dry eye disease, prevents acetominophen toxicity, protects against selenium, mercury, and arsenic toxicity, has shown efficacy against arthritis, may prevent cataracts, may reduce sickness-associated inflammation, reduces liver inflammation, may have efficacy against inflammatory bowel disease, reduces inflammation in prostatitis, reduces damage due to ischemia/reperfusion, reduces the effects of traumatic brain injury (both in preventative and treatment capacities), increases glutathione,improves neuron survival in spinal cord injury, potentiates the immune system, prevents against genotoxic effects of flouride and arsenic, prevents and treats gastric ulcers, reduces DA cell death upon administration of DA neurotoxin (and do so through more than just anti-inflammatory pathways), reduces tolerance to morphine, provides neuroprotection against glutamate excitotoxicity, shows anti-fungal properties, shows anti-viral properties, is a vitamin D receptor agonist, and may reduce certain types of hyperalgesia. It accomplishes these remarkable and diverse feats by increasing glutathione, inhibiting NF-kappaB, inhibiting PGE2 and COX-2, reducing TNF-alpha, IL-8, and IL-1beta, scavenging ROS, reducing iNOS and nitric oxide, increases catalase and superoxide dismutase expression, increasing IL-10, reducing TGF-beta1 activation, reducing astrocyte activation in traumatic brain injury, and normalizing brain levels of BDNF and CREB.
Excellent source of piperine, one of nature's most potent CYP3A4 and Pgp inhibitors. Great way to increase bioavailability/decrease glucuronidation in the liver and the small intestine, and achieve higher concentration of substances that act as CYP3A4 substrates (like curcumin, EGCG etc.). Alot of synthetic drugs are also CYP4A4 substrates, so be careful.
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