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Doctor's Best, SAM-e (S-Adenosyl Methionine), Double Strength, 400 mg, 60 Enteric Coated Tablets

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Doctor's Best, SAM-e (S-Adenosyl Methionine), Double Strength, 400 mg, 60 Enteric Coated Tablets

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Doctor's Best, SAM-e (S-Adenosyl Methionine), Double Strength, 400 mg, 60 Enteric Coated Tablets

In Stock
400 mg
400 mg
200 mg
60 Tablets
30 Tablets
60 Tablets
  • Expiration Date: February 2020
  • Shipping Weight:
    0.3 lbs
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  • Product Code: DRB-00252
  • UPC Code: 753950002524
  • Package Quantity: 60 Tablets
  • Dimensions:
    6.3 x 3.3 x 2 in, 0.25 lbs
    Switch to Metric units

Product Rank:

#87 in Supplements >
Frequently Purchased Together
Product Overview


  • Science-Based Nutrition
  • Helps Enhanced Mood and Neural Function
  • Helps Promote Joint Comfort and Mobility
  • Helps Support Liver Health and Detoxification
  • Vegan
  • Dietary Supplement
  • Gluten Free / Soy Free / Vegan

Our Double Strength SAM-e 400 contains 400 mg of active Soloesse SAM-e in each tablet. Doctor's Best utilizes only the highest quality Italian Soloesse SAM-e available providing slow and targeted release for improved GI tolerance and absorption. This ensures that you receive the most potent SAM-e product with the highest percentage of the active S,S form per serving.

SAM-e (S-Adenosyl Methionine) is naturally produced by your body and helps maintain healthy emotions. Various factors such as diet and aging can cause low levels of SAM-e, leaving you feeling unbalanced and moody. Doctor's Best SAM-e helps replenish your SAM-e levels and promote a healthy mood.

Supplementing with SAM-e

Soloesse Italian SAM-e is processed to yield the highest available percentage of the active pure S,S form which helps mediate bio-chemical activity in the human body.

SAM-e and Mood and Cognitive Function

SAM-e helps facilitate DNA enzymatic actions. These enzymatic actions are required for the healthy conversion of neurotransmitters responsible for healthy emotions, such as serotonin and dopamine. SAM-e also facilitates glutathione usage which improves the body's antioxidant defense and helps maintain acetylcholine levels necessary for cognitive function.

SAM-e and Joint Function

In clinical trials, SAM-e has been shown to help increase joint comfort and mobility by promoting the synthesis of proteoglycans, essential components of connective tissue.

SAM-e and Liver Function

SAM-e helps support healthy levels of glutathione, a critical anti-oxidant which helps protect against free radicals. SAM-e acts as a methyl donor in the synthesis and formation of phosphatidylcholine and L-cysteine, both necessary for maintaining liver health.

Double Strength SAM-e is sealed in blister packs for freshness and stability.

Suggested Use

Adult Use: Take 1 tablet daily away from food, or as recommended by a nutritionally-informed physician. Do not chew or crush tablet.

Other Ingredients

Microcrystalline cellulose, magnesium hydroxide, stearic acid, calcium chloride anhydrous, magnesium stearate, colloidal silica anhydrous, calcium oxide, magnesium silicate, natural food glaze, arginine base, glycerol, sodium alginate.


Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.

Store product in a cool, dry place.

Supplement Facts
Serving Size: 1 tablet
Servings Per Container: 60 servings
  Amount per serving % Daily Value
S-Adenosyl Methionine (from 800 mg SAM-e tosylate disulfate) 400 mg
† Daily Value not established.
iHerb Customer Reviews


Posted by iHerb Customer on March 18 2018 | Verified Purchase

i was advised by my gp to take these and they are very good

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Helpful with depression / anxiety

Posted by iHerb Customer on March 17 2018 | Verified Purchase

The biggest issue I have day to day with my anxiety is how drained I feel by the end of a work day from the constant stress. I found my energy levels improved dramatically taking 1 in the morning before breakfast, with subtle but definite effects to my mood. Less prone to over emotional responses, not as lonely as I normally feel, and a brighter outlook. This definitely works, just not the way that anti depressants do! My hair started growing a lot faster too I found, no idea if that correlates.

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Bring The Smile Back To My Face

Posted by iHerb Customer on March 16 2018 | Verified Purchase

This product is absolutely amazing! It increases my brain ability to learn and be focus in every thing❣️it make you look differently on life, and you have only positive thoughts. It’s also help me to treat my sever clinical depression, and I stop to cry. Now I’m in a very good mood with a smile on my face. I wish 🙏I knew about this product before😘Thanks a lot 🤗👌🏻💯

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Great product! Wish I had known about it sooner!

Posted by iHerb Customer on March 7 2018 | Verified Purchase

This product has done me the world of wonder. I take it most days instead of everyday and it keeps me balanced and content. So happy to have been told about this product

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Good mood from SAM-E

Posted by mozzer on March 4 2018 | Verified Purchase

Improves brain processes that lift mood.

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