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Jarrow Formulas, Natural SAM-e (S-Adenosyl-L-Methionine) 400, 400 mg, 30 Enteric-Coated Tablets

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Jarrow Formulas, Natural SAM-e (S-Adenosyl-L-Methionine) 400, 400 mg, 30 Enteric-Coated Tablets

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Jarrow Formulas, Natural SAM-e (S-Adenosyl-L-Methionine) 400, 400 mg, 30 Enteric-Coated Tablets

In Stock
400 mg
200 mg
400 mg
30 Tablets
60 Tablets
30 Tablets
20 Tablets
  • Expiration Date: November 2019
  • Shipping Weight:
    0.2 lbs
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  • Product Code: JRW-20020
  • UPC Code: 790011200208
  • Package Quantity: 30 Tablets
  • Dimensions:
    1.8 x 3.1 x 5 in, 0.15 lbs
    Switch to Metric units
Frequently Purchased Together
Product Overview


  • Pharmaceutical Grade, Stabilized
  • Full Potency
  • S-Adenosyl Methionine
  • 400 mg (Net Yield) SAM-e from 800 mg SAM-e Tosylate Disulfate
  • Highest Concentration of Active S, S Form
  • 30 Count
  • In Foil Blister Pack
  • Vegan
  • Gluten Free
  • Dietary Supplement


  • Longevity
  • Joint Strength
  • Liver Detoxification
  • Mood and Brain Function

Jarrow Formulas SAM-e 400 provides a full 400 mg SAM-e (net yield) from 800 mg of SAM-e tosylate disulfate. SAM-e 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.

Contains More of the Active S,S Form

Found in all living cells, SAM-e is a metabolite of methionine (an essential amino acid). SAM-e is a chiral molecule and consists of two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas SAM-e is made naturally by microbiological fermentation and then specially processed without solvents to preserve 68-80% (S,S) SAM-e, the highest active level available.

SAM-e has been clinically shown to have the following benefits:

Joint Strength

SAM-e supports the production of healthy connective tissues through transulfuration. In this process, critical components of connective tissue, including glucosamine and the chondroitin sulfates, are sulfated by SAM-e metabolites.

Brain Metabolism

SAM-e methylation reactions are involved in the synthesis of neurotransmitters such as L-DOPA, dopamine and related hormones, serotonin, epinephrine and phosphatidylcholine (a component of lecithin).


Methylation of DNA appears to be important in the suppression of errors in DNA replication. Demethylation of DNA is considered a contributor to the aging process. Proper methylation through substances such as SAM-e positively influences longevity.


SAM-e metabolism supports the synthesis of glutathione (GSH) and glutathione - dependent enzymes (glutathione peroxidase and glutathione - S- transferase), which are substances important for liver function.

Suggested Use

Take 1 tablet per day on an empty stomach, or as directed by your qualified health care consultant.

For best result, use with Jarrow Formulas JarroSil, the biologically Activated Silicon.

Other Ingredients

Cellulose, mannitol, glyceryl behenate, magnesium stearate (vegetable source), silicon dioxide, sodium starch, glycolate, enteric coating (methacrylate copolymers), magnesium silicate, titanium dioxide, triethyl citrate, and riboflavin.

Suitable for vegetarians/vegans

No wheat, no gluten, no soybeans, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts

Full Potency 400 mg SAM-e is derived from 800 mg of SAM-e tosylate disulfate.


Individual using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRI) and MAO Inhibitors should consult a physician before using. Individuals with Parkinson's disease, bi-polar disorder or manic depression should not use SAM-e.

This product complies with the proposed USP Monograph for SAM-e.

Jarrow Formulas Sam-e 400 is foil blister-packed to maximize stability and safety. Do not use if outer seal of blister pack is broken.

Store in a cool, dry place.

Keep out of the reach of children.

Supplement Facts
Serving Size: 1 Tablet
Servings Per Container: 30
 Amount Per Tablet%DV
S-Adenosyl Methionine (from 800 mg of SAM-e tosylate disulfate) 400 mg *
* Daily Value not established.
iHerb Customer Reviews

Happy with Jarrow

Posted by iHerb Customer on November 2 2017 | Verified Purchase

I can really tell the difference in my mood when I don't take Sam-e. Jarrow is a good brand. Works for me.

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Not bad and do give it a try

Posted by iHerb Customer on August 13 2017 | Verified Purchase

I endured pain in the soles of my feet for such a long time because I worked long hours standing and I noticed after taking this for less than a week I didn't feel the pain anymore. Also helps to calm my anxiety a little.

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I use this with DIM and Calcium-D-Glucarate

Posted by iHerb Customer on December 1 2016 | Verified Purchase

I use this to ensure estrogen detox. I have good experience with combining this with DIM and Calcium-D-Glucarate. Read my DIM review.

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Great anti-depresant

Posted by iHerb Customer on November 21 2016 | Verified Purchase

I suffer from chronic depression and this thing is effective for it just like a medicine. I think it is marketed as a medicine in certain countries. Really good.

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Great product!

Posted by iHerb Customer on August 1 2016 | Verified Purchase

Highly recommend for anyone. Helped with my deficiencies, moods and energy. Love this product!

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