header_search header_signed-out header_signed-in header_cart sharefilled circlex
Added to Cart
Cart Total:
Customers Also Bought:
24/7 Help

Doctor's Best, SAM-e, 400 mg , Double-Strength, 30 Enteric Coated Tablets

$19.52 $19.52 (Saved $20.47)

Thank you!

Your email is being processed.

Doctor's Best, SAM-e, 400 mg , Double-Strength, 30 Enteric Coated Tablets

Click to zoom
Our Price:
You Save:
$20.47 (51)
Quantity Discount:
Buy 3+
(5% off)

Sorry, this product is no longer in stock.

Earn 5% Loyalty Credit ?
Combo Discount

Sorry, this product is no longer in stock.

Doctor's Best, SAM-e, 400 mg , Double-Strength, 30 Enteric Coated Tablets

In Stock
400 mg
400 mg
200 mg
30 Tablets
30 Tablets
60 Tablets
  • Expiration Date: March 2020
  • Shipping Weight:
    0.27 lbs
    Switch to Metric units
  • Product Code: DRB-00151
  • UPC Code: 753950001510
  • Package Quantity: 30 Tablets
  • Dimensions:
    1.8 x 3.3 x 6.3 in, 0.15 lbs
    Switch to Metric units

Product Rank:

#60 in Supplements >
Frequently Purchased Together
Product Overview


  • Science-Based Nutrition
  • Enhanced Mood and Neural Function
  • Promotes Joint Comfort and Mobility
  • Supports Liver Health and Detoxification
  • Vegan
  • Dietary Supplement
  • Gluten Free - Soy Free - Vegan

SAM-e (S-Adenosyl Methionine) is derived from the amino acids methionine and ATP (Adenosine Triphosphate). ATP is normally synthesized in the body but may become depleted from sickness and aging. SAM-e is concentrated in the liver and brain and has multiple mechanisms of action in the body. As a major methyl donor, it synthesizes hormones, nucleic acids, proteins, phospholipids, catecholamines, and other neurotransmitters.

Supplementing with SAM-e

The manufacturing process of SAM-e yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form the mediates biochemical- activity in the human body, whereas the R,S for is considered to be biologically inactive. The Italian SAM-e used in our SAM-e 400 is processed to yield the highest available percentage of the active pure S,S form on the market.

SAM-e and Joint Function

In clinical trials, SAM-e has been shown to help reduce pain in joints and increase joint comfort and mobility by promoting the synthesis of proteoglycans, essential components of connective tissue.

SAM-e and Mood and Cognitive Function

SAM-e's ability to boost brain cell methylation facilitates youthful DNA enzymatic actions which may help account for its mood-elevating properties. These enzymatic actions are required for the healthy conversion of neurotransmitters, such a serotonin and dopamine. SAM-e also facilitates glutathione usage which improves the body's antioxidant defense and it helps maintain acetylcholine levels necessary for cognitive function.

SAM-e and Liver Function

In order to perform its detoxification role, SAME-e facilitates healthy methylation enzymatic processes and boost hepatic levels of glutathione, a critical antioxidant which helps protect against free radicals. SAME-e acts as a methyl donor in the synthesis an formation of phosphatidylcholine and L-cysteine, both necessary for maintaining liver health.

Our Double Strength SAM-e 400 contains 400 mg of active SAM-e in each tablet. Doctor's Best utilizes only the highest quality Italian SAM-e available on the market. This ensures that you receive the most potent SAM-e product with the highest percentage of the active S,S form per serving.

Suggested Use

Adult Use: Take 1 tablet daily away from food, or as recommended by a nutritionally-informed physician. Do not chew or crush tablet.

Other Ingredients

Cellulose, methacrylic acid copolymer, glyceryl behenate, magnesium silicate, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silicon dioxide, medium chain triglycerides, sodium carboxymethyl starch and iron oxide.


Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.

Store in a cool dry place.

Double Strength SAM-e 400 is sealed in blister packs for freshness and stability.

Store product in a cool, dry place to ensure maximum quality.

Supplement Facts
Serving Size: 1 Tablet
Servings Per Container: 30 servings
  Amount Per Serving %Daily Value
S-Adenosyl Methionine
(from SAM-e tosylate disulfate)
400 mg
† Daily Value not established.
iHerb Customer Reviews

Other brand better...

Posted by iHerb Customer on March 12 2018 | Verified Purchase

Stomach burn, bowel pain..

Thanks for your feedback!

It freakin works for me

Posted by iHerb Customer on February 1 2018 | Verified Purchase

Drs prescribed 3 diff antidepressants. All had the opposite, paradoxical effect. Sam e makes me feel more hopeful, motivated. Do your own research, try it, don’t take my word for it. Everybody’s different.

Thanks for your feedback!

Great properties

Posted by iHerb Customer on December 22 2017 | Verified Purchase

This product has been a great supplement for three years now.

Thanks for your feedback!


Posted by iHerb Customer on December 12 2017 | Verified Purchase

SAM-e and TMG are this power couple that keep depression away. Aids the methylation cycle

Thanks for your feedback!


Posted by iHerb Customer on December 8 2017 | Verified Purchase

Really positive effect on mood and energy. Loved it!

Thanks for your feedback!