Doctor's Best, SAM-e, 400 mg , Double-Strength, 30 Enteric Coated Tablets
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Expiration Date:Expiration Date
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Our receiving department does its best to verify and then enter the correct expiration dates for all incoming products. However, discrepancies do occur from time to time. This being said, the exceptionally high turnover at iHerb ensures that our inventory is among the freshest in the industry.
Shipping Weight:0.27 lbsSwitch to Metric units
- Product Code: DRB-00151
- UPC Code: 753950001510
- Package Quantity: 30 Tablets
1.8 x 3.3 x 6.3 in, 0.15 lbsSwitch to Metric units
- Science-Based Nutrition
- Enhanced Mood and Neural Function
- Promotes Joint Comfort and Mobility
- Supports Liver Health and Detoxification
- Dietary Supplement
- Gluten Free - Soy Free - Vegan
SAM-e (S-Adenosyl Methionine) is derived from the amino acids methionine and ATP (Adenosine Triphosphate). ATP is normally synthesized in the body but may become depleted from sickness and aging. SAM-e is concentrated in the liver and brain and has multiple mechanisms of action in the body. As a major methyl donor, it synthesizes hormones, nucleic acids, proteins, phospholipids, catecholamines, and other neurotransmitters.
Supplementing with SAM-e
The manufacturing process of SAM-e yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form the mediates biochemical- activity in the human body, whereas the R,S for is considered to be biologically inactive. The Italian SAM-e used in our SAM-e 400 is processed to yield the highest available percentage of the active pure S,S form on the market.
SAM-e and Joint Function
In clinical trials, SAM-e has been shown to help reduce pain in joints and increase joint comfort and mobility by promoting the synthesis of proteoglycans, essential components of connective tissue.
SAM-e and Mood and Cognitive Function
SAM-e's ability to boost brain cell methylation facilitates youthful DNA enzymatic actions which may help account for its mood-elevating properties. These enzymatic actions are required for the healthy conversion of neurotransmitters, such a serotonin and dopamine. SAM-e also facilitates glutathione usage which improves the body's antioxidant defense and it helps maintain acetylcholine levels necessary for cognitive function.
SAM-e and Liver Function
In order to perform its detoxification role, SAME-e facilitates healthy methylation enzymatic processes and boost hepatic levels of glutathione, a critical antioxidant which helps protect against free radicals. SAME-e acts as a methyl donor in the synthesis an formation of phosphatidylcholine and L-cysteine, both necessary for maintaining liver health.
Our Double Strength SAM-e 400 contains 400 mg of active SAM-e in each tablet. Doctor's Best utilizes only the highest quality Italian SAM-e available on the market. This ensures that you receive the most potent SAM-e product with the highest percentage of the active S,S form per serving.
Adult Use: Take 1 tablet daily away from food, or as recommended by a nutritionally-informed physician. Do not chew or crush tablet.
Cellulose, methacrylic acid copolymer, glyceryl behenate, magnesium silicate, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silicon dioxide, medium chain triglycerides, sodium carboxymethyl starch and iron oxide.
Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.
Store in a cool dry place.
Double Strength SAM-e 400 is sealed in blister packs for freshness and stability.
Store product in a cool, dry place to ensure maximum quality.
|Serving Size: 1 Tablet|
|Servings Per Container: 30 servings|
|Amount Per Serving||%Daily Value|
|S-Adenosyl Methionine |
(from SAM-e tosylate disulfate)
|† Daily Value not established.|
Never Take Sam-e without Vitamins B-complex
Never Take Sam-e without Vitamins B-complex
I have been taking this over a month now. good results untill one day i felt fast heart beat and short breath. did some study and took B-complex. Made my heart back to normal in minutes. once again, this is an excelent product but do not take it without vitamin B-COMPLEX.
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Other brand better...
Posted by iHerb Customer on Mar 12, 2018 | Verified Purchase
Stomach burn, bowel pain..
It freakin works for me
Posted by iHerb Customer on Feb 01, 2018 | Verified Purchase
Drs prescribed 3 diff antidepressants. All had the opposite, paradoxical effect. Sam e makes me feel more hopeful, motivated. Do your own research, try it, don’t take my word for it. Everybody’s different.
Posted by iHerb Customer on Dec 22, 2017 | Verified Purchase
This product has been a great supplement for three years now.
Posted by iHerb Customer on Dec 12, 2017 | Verified Purchase
SAM-e and TMG are this power couple that keep depression away. Aids the methylation cycle
Posted by iHerb Customer on Dec 08, 2017 | Verified Purchase
Really positive effect on mood and energy. Loved it!