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Doctor's Best, SAM-e (S-Adenosyl-L-Methionine) 200, 60 Enteric Coated Tablets

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In Stock
  • Expiration Date: Nov 2019
  • Shipping Weight:
    0.25 lbs
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  • Product Code: DRB-00206
  • UPC Code: 753950002067
  • Package Quantity: 60 Enteric Coated Tablets
  • Dimensions:
    6.3 x 3.3 x 1.7 in, 0.15 lbs
    Switch to Metric units
Product Overview


  • Science-Based Nutrition
  • Pharmaceutical Grade
  • Dietary Supplement With 200 mg Active S-Adenosyl Methionine Per Tablet
  • Enhances Mood & Neural Function
  • Promotes Joint Comfort & Mobility
  • Supports Liver Health & Detoxification
  • Vegan
  • Sealed in Blister Packs for Freshness & Convenience

S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.

Supplementing with SAMe

The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in our SAMe 200 is processed to yield the highest available percentage of the active pure S,S form on the market.

SAMe and Joint Function

SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.

SAMe and Neural Health

SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.

SAMe and Liver Function

SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.

Our SAMe 200 contains 200 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.

Suggested Use

Adult use: Take 1 tablet daily away from food, or as recommended by a nutritionally-informed physician. Do not chew or crush tablet.

Other Ingredients

Cellulose, methacrylic acid copolymer, glyceryl behenate, magnesium silicate, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silicon dioxide, medium chain triglycerides, sodium carboxymethyl starch and iron oxide.

The SAMe found in Doctor's Best SAMe 200 mg is free from yeast, dairy, gluten, soy, wheat, and artificial flavoring.

Contains nothing other than listed ingredients.


Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.

SAMe 200 is sealed in blister packs for freshness and stability.

Store product in a cool, dry place to ensure maximum quality.

Supplement Facts
Serving Size: 1 tablet
Servings Per Container: 60 servings
  Amount per serving % Daily Value
S-Adenosyl Methionine (from 400 mg of SAM-e tosylate disulfate) 200 mg
† Daily Value not established.
iHerb Customer Reviews

Glad I gave it a try

Posted by 5375741042654856263 on Mar 21, 2017

Love this product. Has made a huge difference in my sons and my life for anxiety and low mood / deppression. I'm so happy I tryed it. Good thing is you can increase your intake if under greater stress with no nasty side effects . When stress is less simply go down a tablet.

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Works great

Posted by 5641962193700427791 on Mar 15, 2017

Each tablet is blister-pack protected from light/moisture which is very important for SAMe since it is unstable and needs protection to keep fresh. They work great! I have ordered a lot of these shipped to Sweden. Shipping has been fast and cheap as well. I take them with "vitacure methyl plus”.

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Horrible stomach pains!

Posted by 5130332158731218753 on Feb 20, 2017

Contains mannitol in the coating which causes bad stomach issues in a lot of people. I am on of the unlucky ones! There are other brands of SAMe on iherb which don't contain this horrible ingredient, which I will try next.

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Great product great price for relaxation

Posted by Reviewer1213286 on Feb 16, 2017

Taking two times a day will help with mood and better relaxation. If under stress, taking 3 times a day will be extremely helpful. My family has use this for many years

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A bit of a disaster

Posted by Reviewer2000984 on Feb 14, 2017

I've tried SAMe 6 times over the years: once nothing happened, once my mood went up, and the other 4 times I had most unpleasant side effects - disturbed gut, blurry vision, weakness, fatigue, oversleeping, headache, insomnia. Going by a look around the web, these side effects are pretty common. I'm glad I had only one 200mg pill, tho the effects are still with me 4 days after I took it. I won't be taking it again. Approach SAMe with care.

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