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Now Foods, SAM-e (S-Adenosyl-L-Methionine), 100 mg, 60 Tablets

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In Stock
  • Expiration Date: Oct 2018
  • Shipping Weight:
    0.5 lbs
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  • Product Code: NOW-00136
  • UPC Code: 733739001368
  • Package Quantity: 60 Tablets
  • Dimensions:
    2.1 x 2.1 x 3.7 in, 0.3 lbs
    Switch to Metric units
Product Overview


  • Nervous System Support
  • Supports Cartilage Production
  • Enteric Coated
  • A Dietary Supplement
  • Vegetarian/Vegan
  • GMP Quality Assured

SAMe (S-adenosylmethionine), a compound native to the body, is a critical component of many biochemical reactions, including those that affect brain biochemistry and joint health. SAMe is critical for the synthesis of neurotransmitters, is important for energy production in the brain, contributes to the maintenance of healthy cell membrane function, and influences cartilage metabolism. NOW SAMe is enteric-coated, which makes it very well tolerated and protects it from degradation.

Suggested Use

As a dietary supplement, take 1 tablet 2 to 4 times daily, preferably on an empty stomach.

Refrigeration recommended after opening.

Other Ingredients

Cellulose, croscarmellose sodium, magnesium stearate (vegetable source), stearic acid (vegetable source), silica, ascorbic acid, citric acid and enteric coating (cellulose, triethyl citrate, menthacrylic acid).

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.


Do not eat freshness packet. Keep in bottle.

Caution: For adults only. Individuals with bipolar (manic) depression and those with anxiety disorders should not take SAMe unless under professional medical supervision. Consult physician if pregnant/nursing, taking medication, or have a medical condition. Keep out of reach of children.

Supplement Facts
Serving Size: 1 Tablet
  Amount Per Serving %DV
SAMe (S-Adenosyl-L-Methionine) (from 200 mg of S-Adenosyl-L-Methionone Disulfate
100 mg *
* Daily Value not established.
iHerb Customer Reviews

good product

Posted by 5113690239036905659 on Jan 09, 2017

I have been on this product for approximately a week now. It is a clean product (no fillers/good for sensitive people like me) and appears to be working well (alert, less anxiety, or when I become anxious I am aware of it in the moment) although I am finding that there has been an increase in anger? Not sure if this is a side-effect?

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Posted by 5336987499814460415 on Aug 14, 2016

great mood inhancer

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made adhd behaviour WORSE

Posted by adhd-researcher on Jun 26, 2016

as my username suggests, I am on a path to help my daughter with ADHD sam-e is supposed to help but it made her more anxious better stick to TMG, which is the cheaper version of making SAM-E in the body

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Relaxed feeling from being on them for three weeks.

Posted by 5089671050960157615 on Feb 13, 2016

Relaxed feeling felt from SAMe. I have built up each week the dose and am now on 300mg. Highly recommend. In the last couple of days I have introduced AMINO ACID therapy for me which includes this along with SOLGAR bottles of GABA, L-Tyrosine, 5HTP, DLPA. In total four bottles from SOLGAR for my AMINO ACID therapy for CHRONIC MIGRAINES with visual and sensory aura. They work on my brain. Really liking the relaxed feeling I feel on all of these including the SAMe. Like knowing I am doing all I can for my brain naturally, to relax and prevent migraine. Five stars. If this review helped you please press like below. :)

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for my cat

Posted by Katarinatan on Jan 01, 2016

I was advised by my vet to give this to my cat who was diagnosed w liver cancer. This dosage is just perfect for my cat. No need to split any pills tat I m giving to my husband for his excessive drinking and eating.

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