Your Cart is Empty
But it doesn't have to be.
Continue Shopping.
Added to Cart
Cart Total:
Customers Also Bought:

Source Naturals, SAM-e (S-Adenosyl-L-Methionine), 400 mg, 30 Enteric Coated Tablets

Earn 5% Loyalty Credit ?
Our Price:
Shipping Saver ?
You Save:
$21.15 (46)

Sorry, this product is no longer in stock.

This product is already in your Wish List.

View Wish List

This product is now in your Wish List.

View Wish List
In Stock
  • Expiration Date: Jun 2018
  • Shipping Weight:
    0.18 lbs
    Switch to Metric units
  • Product Code: SNS-01400
  • UPC Code: 021078014003
  • Package Quantity: 30 Enteric Coated Tablets
  • Dimensions:
    1.5 x 3.3 x 5.1 in, 0.15 lbs
    Switch to Metric units
Product Overview


  • Supports Joint Comfort, Function and Mobility
  • Double Strength
  • Dietary Supplement
  • S-Adenosyl-L-Methionine

Source Naturals SAMe is a stable, bioavailable form of S-adenosyl-L-methionine. These tablets are enteric coated and blister packed to prevent breakdown and inactivation of the ingredients.

Dozens of clinical studies have demonstrated that SAMe supports joint comfort, function and mobility in the spine, hips and knees. It is important to the joints because of its critical role in cartilage formation. SAMe helps to form proteoglycans, which are used to renew the matrix of cartilage.

The studies also show that SAMe helps support a positive outlook. It is able to cross the blood-brain barrier, where it affects the synthesis and activation of various proteins, such as neurotransmitters. SAMe also plays a role in transmethylation. Transmethylation reactions affect the synthesis, activation, and metabolism of various biological molecules. Some compounds that SAMe methylates are phospholipids. This is a fundamental step in the mediation of cell to cell communication.

SAMe is present in every living cell in the body and plays an important part in many critical cellular functions. However, levels of SAMe tend to decline with age.

Suggested Use

1 tablet, 1 to 3 times daily. Take tablets on an empty stomach.

Other Ingredients

Cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, silica, stearic acid, glyceryl triacetate, sodium starch glycolate, modified cellulose gum, titanium dioxide and yellow ochre.

Suitable for vegetarians. Contains no yeast, dairy, egg, gluten, soy or wheat. Contains no sugar, salt, preservatives, or artificial flavor or fragrance.


If you are pregnant, may become pregnant, breastfeeding or are taking antidepressant medication, consult your physician before using this product. Use this product under medical supervision if you have bipolar disorder. In a small percentage of people this product may cause nausea or gastrointestinal upset. If you experience discomfort, discontinue use.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

Supplement Facts
Serving Size: 1 Tablet
Servings Per Container: 30
  Amount Per Servings % Daily Value
SAMe (s-adenosyl-L-methionine) from 800 mg of SAMe disulfate tosylate 400 mg
†Daily Value not established.
iHerb Customer Reviews

Didn't notice much difference with 800 mg/day

Posted by 5240434867861180387 on Mar 16, 2017

I have previously had great results taking Samyr (SAM-e sold in Italian pharmacies). With Source Naturals' SAM-e, I noticed only a slight change of mood and only for a few days. A couple of times I woke up feeling nauseous after having taken this product earlier in the day. I took 800 mg a day, and I took two tablets at once. Perhaps it is better to take 1 tablet four times a day.

Verified Purchase

Was this review helpful to you?

Thanks for your feedback!

best treatment for depression

Posted by 5032829859024995117 on Nov 30, 2016

I spent years playing medication roulette trying to treat my depression with prescription and over-the-counter supplements before finally trying SAM-e. 800 mg every morning works better than anything else I've tried, and Source Naturals has delivered the most consistent results for me.

Verified Purchase

Was this review helpful to you?

Thanks for your feedback!

I am definitely happier after using this product for 2 weeks

Posted by 5375783669111175622 on Oct 18, 2016

I can vouch that it worked for me. Two and a half weeks later I am feeling more optimistic and steadier. Pre menopausal blues have started to lift. I am hesitant to recommend it as a natural anti depressant because I know it does not work for everyone. In saying that, it worked for me and I am grateful.

Verified Purchase

Was this review helpful to you?

Thanks for your feedback!

Great Product

Posted by 5586896955355261579 on Jan 08, 2014

Great product, very effective. Been using for a month and will continue to use. Has improve my general well being. Mood, mobility and funny enough my skin complexion.

Verified Purchase

Was this review helpful to you?

Thanks for your feedback!


Posted by 5219846649855951187 on Dec 27, 2013

Find it helps distress and relax, use it along with St Johns Wort, is just the extra boost needed to help cope with looking after both wife and father-in-law, who both have cancer.

Verified Purchase

Was this review helpful to you?

Thanks for your feedback!