Page 3 - Reviews - 21st Century, Niacin, Inositol Hexanicotinate, 500 mg, 110 Capsules - iHerb
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Customer Ratings & Reviews





Posted on Sep 17, 2012
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This is the form of niacin that is best slow release form (doesn't cause flushing). Interestingly the research says it doesn't work... but my blood results show it does: cholesterol, Free Fatty Acids, homocysteine, glucose, C-Reactive Protein, HBa1c, etc... are all in the normal range after taking this. Same in my mother. The other slow release form is niacinamide is slow release but doesn't have the benefits of hexanicotinate. You can also get normal slow release niacin in a wax... but the problem is that if you take it on an empty stomach it dissolves too quickly and you flush like a fire truck. It's less intense than the normal niacin... but if you happen to mix it with something else like alpha lipoic acid... you can still flush... even if you took it with a meal. Niacin that makes you flush is recommended but the flush is very uncomfortable. This goes double if you're in public... as you can look like a fire truck (bright red). People won't believe you're OK and make a fuss. The flush goes within about 30 minutes... but it's a LONG 30 minutes! This slow release form solves that problem while being a large enough dose to do a lot of good. Even if you take some ALA or DMSO (or something else that potentiates its effect) you're unlikely to trigger a flush that is visible to anyone else or more than mildly uncomfortable. I'm using it to keep my mums blood pressure down. It seems to have a bit of a diuretic effect. She had to take 3 a day get the BP down initially but now she's down to just one. Nice bit of chemistry... they hooked 6 niacins into an inositol molecule... and they pop off one by one. In the niacinamide they add an amide (-NH2) group... which seems to change the way it works (doesn't show the same benefits). I like this dose... take one just before going to sleep. Only side effect that is annoying is blurry vision (this disappears with extended use). If you take it just before going to sleep blurry vision isn't going to bother you much. Seems to put a damper on hunger really effectively (burn energy better?). I tried larger doses... but at least for me 500mg at night seems to be a sweet spot. Seems to be very effective at lowering homocysteine... but more pleasant than taking folate (which also works well at lowering cholesterol). Try this before starting statins? ...or instead of statins? :-) P.S 10 years ago I went to the doctors with high cholesterol, homocysteine and FFA's. A week later they were in the normal range (we used B-complex (which includes about 100 mg of B3), B6 and Folic acid). The rapid turn around surprised my doctor. Similar story for my mum except she was already taking the B-complex. Adding this slow release B3 was enough to push her results into the normal range... where they have now been for about 10 years.