Our 13 year old dog always goes crazy when we give these to her! We also give Life extension's dog mix (see review on our page) which combined to these have given our dog so much vitality, and makes her act like she is 4-5 years younger! It's probable that the more you can see the signs of aging on your dog right now the more you will see differences with these. We warmly recommend to at least give these products a try! If you liked this review please click "YES" below.