I normally have issues with gluten, lactose and casein. I am not celiac, but I do have fructose malabsorption. I have avoided both gluten and dairy for years. I've been testing Digest Spectrum for about two weeks now, and taking one of these during my meal has really made a big difference! I can eat gluten and dairy again!!! I am VERY pleased!! For fructose malabsorbers: FYI, I still have to avoid fructose and fructans. I don't ever have whole wheat, only white wheat products. UPDATE: I've been using DS for about 6 months now. It is GREAT! It is so nice to be able to have dairy and wheat again!