I started Dixie on the Sea Mussel nutritional remedy (2 caps twice/day) and within 24 hrs, she had stopped growling at me, and had noticeably improved in other ways, as well. Although she is still limping somewhat, she is so greatly improved otherwise-her mood and disposition-compared to where she was on Wed, 06/13/2012--the day that we went to the animal clinic for her annual boosters. Her new daily natural remedy regimen is as follows: 2 caps Sea Mussel (AM & PM doses), 1/2 dropper dose of HyaFlex H.A. (every day mixed into her dinner), and 1 cap MSM (AM & PM doses). All of these doses are managed with the "Greenies Allergy Formula Pill Pockets" & cooked salmon chunks, to disguise the larger caps' taste. I discussed all of the nutritional supplements that I'm giving her with her veterinarian, and she approved of my plan. *Actually, Dixie and I are taking essentially the same supplements for the same ailment (arthritis). That's what originally prompted me to seek out canine equivalents to the supplements that I have been using with great success.* I can only expect that she'll do better and better as the days progress. PTL!