I take it before sleep. On the next day, I always feel sense of warmness around my body. It doesn't happen if I just take beta glucan product. In addition, I find that I sleep better and my mood has been better. The effect of mood is subtle but I certainly feel it. This product is a little more expensive than the Now beta glucan + maitake combo. However, I certainly think that this product is a better deal because it has 250 mg beta glucan. The Now beta glucan + maitake combo has only 100 mg. According to sourcenatural website, you have to consume 2mg / kg of your body weight to maintain a healthy immune system.