I'm a mother of three who works full time and was very run down and catching every infection that my kids brought home and no matter how much rest I got, I was always tired. My gut feeling was that my adrenals were involved so I did some research on adrenal fatigue and general tonics / boosters. I started taking Eleuthero, Astragalus, CoEnzyme Q10 and D-Ribose, plus a general multivitamin. The difference is incredible. We are 2 months into winter here in Australia and by this stage I would normally have had at least three bad chest infections. I haven't had a single one. I have started feeling like I was getting a cold a couple of times but the next day it would have gone. My immune system is clearly on fire. I will definitely keep taking this combo and keep ordering it from iHerb - LOVE the low cost international shipping!