I have adrenal failure and am dependent on supplementation. This product has been excellent so far. I don't know what I would do if it no longer was available. It upsets me that people don't do proper research and ignore warnings. UNLESS you have a serious condition that demands natural glandular replacement (as an alternative to synthetic steroids) DO NOT TRY this product. For us that are unable to tolerate the synthetic steroids, this is a God-send.I have no problems whatsoever, and I have successfully restored adrenal health. I do feel sorry for the reviewer who ended up in ER, but I wish they provided the reason for their experimenting with this potentially harmful supplement, rather than giving it one star review. If taken for a correct diagnosis, the dose is individual and must be divided in several portions daily (anything from a capsule to 3, depending on condition). This is not a supplement for casual use. I have taken it for five years without side effects, rather recovering very well. I found I had to lower the dose, but due to genetic causes and several burnouts,I will have to take this for the rest of my life. Please understand that some of us are dependent on this glandular. For anyone else, do take the disclaimers and warnings seriously.