iHerb Customer Reviews
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No thanks - may worsen CFS, adrenal dysfunction, MCS, et al
Posted by Health-Is-Wealth on Mar 11, 2014
Genistein inhibits two crucial enzymes - 3-beta-hydroxysteroid-dehydrogenase (3B-HSD) and 21-hydroxylase. These enzymes are responsible for converting cholesterol to progesterone and cortisol. 3B-HSD also affects synthesis of other hormones. Inhibiting the aforementioned enzymes has repercussions for energy production, among other things - especially if there are any other issues with synthesis/conversion of cholesterol (e.g. lacking nutrients, defective pathway). Genistein may therefore worsen CFS/adrenal dysfunction. Tyrosinase is a copper enzyme. 'Increased manganese intake impairs the activity of copper metallo-enzymes' - from The Clinical Effects of Manganese by E. Blaurock-Busch, PhD - if your goal is to inhibit tyrosinases, you could try taking manganese instead (it's cheaper). Some other options are turmeric (also inhibits tyrosinases, e.g. tyrosine hydroxylase), chick peas (aka Garbanzo Beans, contain same isoflavones, though less of). If any/all of those things cause you to feel awful - then inhibiting tyrosinase is not such a good idea and/or there's possibly an iron issue. If this review was helpful to you, please click YES below - thank you. For reviews of all the products I have purchased from iHerb, please click my username above.
Posted by Reviewer1435757 on Nov 22, 2008
After 2 weeks no change. Product most likly needs a much longer time to start working and bring a change.
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